Systemic immune response after laparoscopic and open cholecystectomy

Shyr Ming Sheen-Chen, Han Shiang Chen, Hock Liew Eng, Wei Jen Chen, Bruno Jawan

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The laparoscopic approach is thought to reduce the postoperative immunologic and metabolic effects of an open operation. This study was designed with the aim of comparing the systemic immune response after laparoscopic and open cholecystectomy. Seventeen patients with gallbladder stones were assigned to undergo either a laparoscopic (n = 9) or open (n = 8) approach. The postoperative immune response was assessed by measuring the serum levels of soluble Fas (sFas), soluble L-selectin (sL-selectin), and transforming growth factor-β1 (TGFβ1) preoperatively and 2 hours, 1 day, and 2 days postoperatively. Both approaches resulted in a significant decrease in sFas levels 1 and 2 days postoperatively. The open approach evoked a transient increase in sL-selectin levels 2 hours postoperatively. Moreover, the open approach resulted in a persistent, significant increase in TGFβ1 levels postoperatively. Comparison of open versus laparoscopic cholecystectomy has shown no significant difference in sFas level and a statistically significant increase of sL-selectin (within 2 hours) and TGFβ levels after open surgery. Although both laparoscopic and open cholecystectomy evoked an alteration of the systemic immune response, our data showed that such immune response may be less after the laparoscopic approach.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalWorld Journal of Surgery
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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