Systemic immune response after laparoscopic and open cholecystectomy

Shyr Ming Sheen-Chen, Han Shiang Chen, Hock Liew Eng, Wei Jen Chen, Bruno Jawan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The laparoscopic approach is thought to reduce the postoperative immunologic and metabolic effects of an open operation. This study was designed with the aim of comparing the systemic immune response after laparoscopic and open cholecystectomy. Seventeen patients with gallbladder stones were assigned to undergo either a laparoscopic (n = 9) or open (n = 8) approach. The postoperative immune response was assessed by measuring the serum levels of soluble Fas (sFas), soluble L-selectin (sL-selectin), and transforming growth factor-β1 (TGFβ1) preoperatively and 2 hours, 1 day, and 2 days postoperatively. Both approaches resulted in a significant decrease in sFas levels 1 and 2 days postoperatively. The open approach evoked a transient increase in sL-selectin levels 2 hours postoperatively. Moreover, the open approach resulted in a persistent, significant increase in TGFβ1 levels postoperatively. Comparison of open versus laparoscopic cholecystectomy has shown no significant difference in sFas level and a statistically significant increase of sL-selectin (within 2 hours) and TGFβ levels after open surgery. Although both laparoscopic and open cholecystectomy evoked an alteration of the systemic immune response, our data showed that such immune response may be less after the laparoscopic approach.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalWorld Journal of Surgery
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 1 2002
Externally publishedYes

Fingerprint

L-Selectin
Laparoscopic Cholecystectomy
Transforming Growth Factors
Gallbladder
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Systemic immune response after laparoscopic and open cholecystectomy. / Sheen-Chen, Shyr Ming; Chen, Han Shiang; Eng, Hock Liew; Chen, Wei Jen; Jawan, Bruno.

In: World Journal of Surgery, Vol. 26, No. 12, 01.12.2002, p. 1418-1422.

Research output: Contribution to journalArticle

Sheen-Chen, Shyr Ming ; Chen, Han Shiang ; Eng, Hock Liew ; Chen, Wei Jen ; Jawan, Bruno. / Systemic immune response after laparoscopic and open cholecystectomy. In: World Journal of Surgery. 2002 ; Vol. 26, No. 12. pp. 1418-1422.
@article{0c6c63da962544289906c07e30a2ff90,
title = "Systemic immune response after laparoscopic and open cholecystectomy",
abstract = "The laparoscopic approach is thought to reduce the postoperative immunologic and metabolic effects of an open operation. This study was designed with the aim of comparing the systemic immune response after laparoscopic and open cholecystectomy. Seventeen patients with gallbladder stones were assigned to undergo either a laparoscopic (n = 9) or open (n = 8) approach. The postoperative immune response was assessed by measuring the serum levels of soluble Fas (sFas), soluble L-selectin (sL-selectin), and transforming growth factor-β1 (TGFβ1) preoperatively and 2 hours, 1 day, and 2 days postoperatively. Both approaches resulted in a significant decrease in sFas levels 1 and 2 days postoperatively. The open approach evoked a transient increase in sL-selectin levels 2 hours postoperatively. Moreover, the open approach resulted in a persistent, significant increase in TGFβ1 levels postoperatively. Comparison of open versus laparoscopic cholecystectomy has shown no significant difference in sFas level and a statistically significant increase of sL-selectin (within 2 hours) and TGFβ levels after open surgery. Although both laparoscopic and open cholecystectomy evoked an alteration of the systemic immune response, our data showed that such immune response may be less after the laparoscopic approach.",
author = "Sheen-Chen, {Shyr Ming} and Chen, {Han Shiang} and Eng, {Hock Liew} and Chen, {Wei Jen} and Bruno Jawan",
year = "2002",
month = "12",
day = "1",
doi = "10.1007/s00268-002-6388-3",
language = "English",
volume = "26",
pages = "1418--1422",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "Springer New York LLC",
number = "12",

}

TY - JOUR

T1 - Systemic immune response after laparoscopic and open cholecystectomy

AU - Sheen-Chen, Shyr Ming

AU - Chen, Han Shiang

AU - Eng, Hock Liew

AU - Chen, Wei Jen

AU - Jawan, Bruno

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The laparoscopic approach is thought to reduce the postoperative immunologic and metabolic effects of an open operation. This study was designed with the aim of comparing the systemic immune response after laparoscopic and open cholecystectomy. Seventeen patients with gallbladder stones were assigned to undergo either a laparoscopic (n = 9) or open (n = 8) approach. The postoperative immune response was assessed by measuring the serum levels of soluble Fas (sFas), soluble L-selectin (sL-selectin), and transforming growth factor-β1 (TGFβ1) preoperatively and 2 hours, 1 day, and 2 days postoperatively. Both approaches resulted in a significant decrease in sFas levels 1 and 2 days postoperatively. The open approach evoked a transient increase in sL-selectin levels 2 hours postoperatively. Moreover, the open approach resulted in a persistent, significant increase in TGFβ1 levels postoperatively. Comparison of open versus laparoscopic cholecystectomy has shown no significant difference in sFas level and a statistically significant increase of sL-selectin (within 2 hours) and TGFβ levels after open surgery. Although both laparoscopic and open cholecystectomy evoked an alteration of the systemic immune response, our data showed that such immune response may be less after the laparoscopic approach.

AB - The laparoscopic approach is thought to reduce the postoperative immunologic and metabolic effects of an open operation. This study was designed with the aim of comparing the systemic immune response after laparoscopic and open cholecystectomy. Seventeen patients with gallbladder stones were assigned to undergo either a laparoscopic (n = 9) or open (n = 8) approach. The postoperative immune response was assessed by measuring the serum levels of soluble Fas (sFas), soluble L-selectin (sL-selectin), and transforming growth factor-β1 (TGFβ1) preoperatively and 2 hours, 1 day, and 2 days postoperatively. Both approaches resulted in a significant decrease in sFas levels 1 and 2 days postoperatively. The open approach evoked a transient increase in sL-selectin levels 2 hours postoperatively. Moreover, the open approach resulted in a persistent, significant increase in TGFβ1 levels postoperatively. Comparison of open versus laparoscopic cholecystectomy has shown no significant difference in sFas level and a statistically significant increase of sL-selectin (within 2 hours) and TGFβ levels after open surgery. Although both laparoscopic and open cholecystectomy evoked an alteration of the systemic immune response, our data showed that such immune response may be less after the laparoscopic approach.

UR - http://www.scopus.com/inward/record.url?scp=0036886006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036886006&partnerID=8YFLogxK

U2 - 10.1007/s00268-002-6388-3

DO - 10.1007/s00268-002-6388-3

M3 - Article

C2 - 12297934

AN - SCOPUS:0036886006

VL - 26

SP - 1418

EP - 1422

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

IS - 12

ER -