System-based strategy for the management of meconium aspiration syndrome: 198 Consecutive cases observations

Hung Chih Lin, Bai Horng Su, Tsung Wen Lin, Chang Hai Tsai, Tsu Fuh Yeh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To evaluate whether the system-based strategy for management of meconium aspiration syndrome (MAS) could reduce the morbidity and mortality rate of MAS in our institute, a prospective consecutive clinical observation was conducted. System-based strategy including appropriately trained the relevant medical staff to familiar with neonatal resuscitation program, early surfactant replacement or lavage following with high-frequency ventilator (HFV) and/or inhaled nitric oxide (iNO). Outcome measurements were the morbidity and mortality rates of MAS. All infants of MAS in the study period were included except cases of congenital malformations or cyanotic congenital heart disease (CHD). Oxygen, nasal continuous positive airway pressure (CPAP), and intermittent mandatory ventilation (IMV) were applied as clinically indicated. Surfactant was used as replacement or lavage therapy for MAS infants whose oxygen index (OI) exceeded 20 or value for AaDO 2 exceeded 400 within 6 hours of age. High-frequency oscillator ventilation (HFO) was applied for infants of MAS that demonstrated intractable respiratory failure with conventional mechanical ventilation and 100% oxygen. Inhaled nitric oxide (iNO) was used with IMV or HFO for infants of persistent pulmonary hypertension (PPHN) when it was unresponsive to conventional therapy. Dexamethasone was prescribed in infants of severe hypotension that did not respond to dopamine and epinephrine. A series of 198 consecutive infants of MAS born in this hospital during 9 years were analyzed. There was no mortality. Fourteen infants developed PPHN, 11 had pneumothorax, 1 had pulmonary hemorrhage, 2 had neurologic sequelae because of severe asphyxia, and 2 developed bronchopulmonary dysplasia. Our results indicated that appropriately trained relevant medical staff with neonatal resuscitation program to avoid complicated MAS and early surfactant replacement or lavage following with HFO and/or iNO could reduce the morbidity and mortality rate of MAS even without extracorporeal membrane oxygenation (ECMO).

Original languageEnglish
JournalActa Paediatrica Taiwanica
Volume46
Issue number2
Publication statusPublished - Mar 1 2005
Externally publishedYes

Fingerprint

Meconium Aspiration Syndrome
High-Frequency Ventilation
Therapeutic Irrigation
Surface-Active Agents
Nitric Oxide
Mortality
Medical Staff
Oxygen
Morbidity
Pulmonary Hypertension
Resuscitation
Ventilation
Bronchopulmonary Dysplasia
Extracorporeal Membrane Oxygenation
Continuous Positive Airway Pressure
Asphyxia
Pneumothorax
Mechanical Ventilators
Artificial Respiration
Respiratory Insufficiency

Keywords

  • Meconium aspiration syndrome
  • Mortality
  • Persistent pulmonary hypertension
  • Pneumothorax

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

System-based strategy for the management of meconium aspiration syndrome : 198 Consecutive cases observations. / Lin, Hung Chih; Su, Bai Horng; Lin, Tsung Wen; Tsai, Chang Hai; Yeh, Tsu Fuh.

In: Acta Paediatrica Taiwanica, Vol. 46, No. 2, 01.03.2005.

Research output: Contribution to journalArticle

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