Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma

Ian Magrath, Jan Erikson, Jacqueline Whang-Peng, Hauke Sieverts, Gary Armstrong, David Benjamin, Timothy Triche, Oliver Alabaster, Carlo M. Croce

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54 Citations (Scopus)

Abstract

Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the κ type, in contrast to the usual concordance between a translocation involving chromosome 22 and λ chain synthesis. Both κ genes and one λ gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.

Original languageEnglish
Pages (from-to)1094-1098
Number of pages5
JournalScience
Volume222
Issue number4628
Publication statusPublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • General

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