Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma

Ian Magrath, Jan Erikson, Jacqueline Whang-Peng, Hauke Sieverts, Gary Armstrong, David Benjamin, Timothy Triche, Oliver Alabaster, Carlo M. Croce

Research output: Contribution to journalArticle

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Abstract

Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the κ type, in contrast to the usual concordance between a translocation involving chromosome 22 and λ chain synthesis. Both κ genes and one λ gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.

Original languageEnglish
Pages (from-to)1094-1098
Number of pages5
JournalScience
Volume222
Issue number4628
Publication statusPublished - Jan 1 1983
Externally publishedYes

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Genetic Translocation
Immunoglobulin Genes
Burkitt Lymphoma
Light
Chromosomes, Human, Pair 22
Cell Line
Chromosomes, Human, Pair 8
Gene Rearrangement
Human Herpesvirus 4
Fetal Blood
Genes
Immunoglobulin M
Acquired Immunodeficiency Syndrome
Chromosomes
Lymphocytes
Antigens
Sexual Minorities

ASJC Scopus subject areas

  • General

Cite this

Magrath, I., Erikson, J., Whang-Peng, J., Sieverts, H., Armstrong, G., Benjamin, D., ... Croce, C. M. (1983). Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma. Science, 222(4628), 1094-1098.

Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma. / Magrath, Ian; Erikson, Jan; Whang-Peng, Jacqueline; Sieverts, Hauke; Armstrong, Gary; Benjamin, David; Triche, Timothy; Alabaster, Oliver; Croce, Carlo M.

In: Science, Vol. 222, No. 4628, 01.01.1983, p. 1094-1098.

Research output: Contribution to journalArticle

Magrath, I, Erikson, J, Whang-Peng, J, Sieverts, H, Armstrong, G, Benjamin, D, Triche, T, Alabaster, O & Croce, CM 1983, 'Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma', Science, vol. 222, no. 4628, pp. 1094-1098.
Magrath, Ian ; Erikson, Jan ; Whang-Peng, Jacqueline ; Sieverts, Hauke ; Armstrong, Gary ; Benjamin, David ; Triche, Timothy ; Alabaster, Oliver ; Croce, Carlo M. / Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma. In: Science. 1983 ; Vol. 222, No. 4628. pp. 1094-1098.
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