Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

Der Zen Liu, Supachok Sinchaikul, Peddiahgari Vasu Govardhana Reddy, Meng Yang Chang, Shui Tein Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.

Original languageEnglish
Pages (from-to)617-620
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number3
DOIs
Publication statusPublished - Feb 1 2007

Fingerprint

Paclitaxel
Cells
Glucose
Neoplasms
Facilitative Glucose Transport Proteins
MCF-7 Cells
Succinic Acid
Cytotoxicity
Pharmaceutical Preparations
Solubility
2'-paclitaxel methyl 2-glucopyranosyl succinate
Therapeutics

Keywords

  • Cancer cells
  • Glucose
  • Paclitaxel
  • Targeted delivery

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells. / Liu, Der Zen; Sinchaikul, Supachok; Reddy, Peddiahgari Vasu Govardhana; Chang, Meng Yang; Chen, Shui Tein.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 3, 01.02.2007, p. 617-620.

Research output: Contribution to journalArticle

Liu, Der Zen ; Sinchaikul, Supachok ; Reddy, Peddiahgari Vasu Govardhana ; Chang, Meng Yang ; Chen, Shui Tein. / Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 3. pp. 617-620.
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