Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

Der Zen Liu, Supachok Sinchaikul, Peddiahgari Vasu Govardhana Reddy, Meng Yang Chang, Shui Tein Chen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.

Original languageEnglish
Pages (from-to)617-620
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number3
DOIs
Publication statusPublished - Feb 1 2007

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Keywords

  • Cancer cells
  • Glucose
  • Paclitaxel
  • Targeted delivery

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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