Synthesis of 1,2,3-triazole tethered bifunctional hybrids by click chemistry and their cytotoxic studies

Jagjeet Singh, Sahil Sharma, A. K. Saxena, Kunal Nepali, Preet Mohinder Singh Bedi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In view of the drug resistance with most of the currently used anticancer drugs, molecular hybrids of pyrazolyl chalcones and p-nitro benzyl functionalities tethered by triazole ring have been synthesised and evaluated for cytotoxic studies against three human cancer cell lines (THP, COLO-205, A-549). The results of the preliminary investigation exhibited marked dependence of the cytotoxic activity on the electronic factors. Placement of naphthyl (JGPT-11) and trimethoxy phenyl ring (JGPT-6) as ring A proved to be extremely beneficial in enhancing the cytotoxic potential. Thus we herein report the synthesis and cytotoxic studies of a new class of molecular hybrids. Detailed investigation on the biological mechanistic insights of JGPT-11 and 6 is under progress.

Original languageEnglish
Pages (from-to)3160-3169
Number of pages10
JournalMedicinal Chemistry Research
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 1 2013
Externally publishedYes

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Keywords

  • Cancer
  • Cell lines
  • Cytotoxicity
  • Molecular hybrids
  • Resistance

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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