Synthesis of α‐Methyldopa Prodrugs Containing Dipeptide Moieties as Tools for Intestinal Delivery

Hui‐Po ‐P Wang, Chih‐Yuan ‐Y Cheng, Jin‐Ran ‐R Ma, Jia‐Shuai ‐S Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dipeptides containing D‐phenylglycine or D‐p‐hydroxyphenylglycine were attached onto the antihypertensive agent α‐methyldopa to form prodrugs 1a, 1b and 1c. The nonessential amino acids were introduced into the prodrug molecules as tools of chemical delivery to improve the intestinal absorption of the parent drug. Preliminary tests revealed that the prodrugs were stable in phosphate buffer solutions at pH 7.4 (t1/2 > 10 h). These compounds also demonstrated satisfactory stability toward enzymatic degradation in a mucosa preparation isolated from rat intestine, indicating that they might be feasibly formulated as an oral prodrug of α‐methyldopa.

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalJournal of the Chinese Chemical Society
Volume42
Issue number3
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Methyldopa
Dipeptides
Prodrugs
Antihypertensive Agents
Rats
Buffers
Phosphates
Amino Acids
Degradation
Molecules
Pharmaceutical Preparations

Keywords

  • Dipeptides as tools for intestinal delivery
  • α‐Methyldopa prodrugs

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis of α‐Methyldopa Prodrugs Containing Dipeptide Moieties as Tools for Intestinal Delivery. / Wang, Hui‐Po ‐P; Cheng, Chih‐Yuan ‐Y; Ma, Jin‐Ran ‐R; Lee, Jia‐Shuai ‐S.

In: Journal of the Chinese Chemical Society, Vol. 42, No. 3, 1995, p. 561-567.

Research output: Contribution to journalArticle

Wang, Hui‐Po ‐P ; Cheng, Chih‐Yuan ‐Y ; Ma, Jin‐Ran ‐R ; Lee, Jia‐Shuai ‐S. / Synthesis of α‐Methyldopa Prodrugs Containing Dipeptide Moieties as Tools for Intestinal Delivery. In: Journal of the Chinese Chemical Society. 1995 ; Vol. 42, No. 3. pp. 561-567.
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