Abstract
Ibuprofen, one of the most widely used non-steroidal anti-inflammatory drug, is an aryl acetic acid derivative, which is an active ingredient in variety of oral formulations such as tablets, gel, pellets, and syrup dosage forms used worldwide. Gastric side effects of ibuprofen are attributed to the presence of free - COOH group and inhibition of endogenous prostaglandins. In recent years, considerable research has been directed at designing prodrugs of ibuprofen with reduced gastro-intestinal toxicity. Numerous ester and amide prodrugs of ibuprofen have been reported. With this background, the present work involves the synthesis, analytical method development, in-vitro hydrolysis, bioanalytical method development, and pharmacokinetics study of an amide prodrug of Ibuprofen coded as TRB-559.
| Original language | English |
|---|---|
| Pages (from-to) | 261-271 |
| Number of pages | 11 |
| Journal | Current Pharmaceutical Analysis |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 23 2012 |
| Externally published | Yes |
Fingerprint
Keywords
- Analgesic
- Bioanalytical Method Development
- Drug Release
- In Vitro Hydrolysis
- Non- Steroidal Antiinflammatory Drugs
- Pharmacokinetics
- Pharmacokinetics Study
- Prodrug
- Prostaglandins
- Validation
ASJC Scopus subject areas
- Pharmaceutical Science
- Molecular Medicine
- Biochemistry
- Biophysics
Cite this
Synthesis, in vitro hydrolysis, bioanalytical method development and pharmacokinetic study of an amide Prodrug of Ibuprofen. / Ojha, Ritu; Nepali, Kunal; Goyal, Rohit; Dhar, Kanaya Lal; Bhardwaj, Tilakraj.
In: Current Pharmaceutical Analysis, Vol. 8, No. 3, 23.07.2012, p. 261-271.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis, in vitro hydrolysis, bioanalytical method development and pharmacokinetic study of an amide Prodrug of Ibuprofen
AU - Ojha, Ritu
AU - Nepali, Kunal
AU - Goyal, Rohit
AU - Dhar, Kanaya Lal
AU - Bhardwaj, Tilakraj
PY - 2012/7/23
Y1 - 2012/7/23
N2 - Ibuprofen, one of the most widely used non-steroidal anti-inflammatory drug, is an aryl acetic acid derivative, which is an active ingredient in variety of oral formulations such as tablets, gel, pellets, and syrup dosage forms used worldwide. Gastric side effects of ibuprofen are attributed to the presence of free - COOH group and inhibition of endogenous prostaglandins. In recent years, considerable research has been directed at designing prodrugs of ibuprofen with reduced gastro-intestinal toxicity. Numerous ester and amide prodrugs of ibuprofen have been reported. With this background, the present work involves the synthesis, analytical method development, in-vitro hydrolysis, bioanalytical method development, and pharmacokinetics study of an amide prodrug of Ibuprofen coded as TRB-559.
AB - Ibuprofen, one of the most widely used non-steroidal anti-inflammatory drug, is an aryl acetic acid derivative, which is an active ingredient in variety of oral formulations such as tablets, gel, pellets, and syrup dosage forms used worldwide. Gastric side effects of ibuprofen are attributed to the presence of free - COOH group and inhibition of endogenous prostaglandins. In recent years, considerable research has been directed at designing prodrugs of ibuprofen with reduced gastro-intestinal toxicity. Numerous ester and amide prodrugs of ibuprofen have been reported. With this background, the present work involves the synthesis, analytical method development, in-vitro hydrolysis, bioanalytical method development, and pharmacokinetics study of an amide prodrug of Ibuprofen coded as TRB-559.
KW - Analgesic
KW - Bioanalytical Method Development
KW - Drug Release
KW - In Vitro Hydrolysis
KW - Non- Steroidal Antiinflammatory Drugs
KW - Pharmacokinetics
KW - Pharmacokinetics Study
KW - Prodrug
KW - Prostaglandins
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=84863955168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863955168&partnerID=8YFLogxK
U2 - 10.2174/157341212801619333
DO - 10.2174/157341212801619333
M3 - Article
AN - SCOPUS:84863955168
VL - 8
SP - 261
EP - 271
JO - Current Pharmaceutical Analysis
JF - Current Pharmaceutical Analysis
SN - 1573-4129
IS - 3
ER -