Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin

Sanath K. Meegalla, Gregory J. Stevens, Charlene A. McQueen, Allan Y. Chen, Chiang Yu, Leroy F. Liu, Leroy-Fong Liu, Edmond J. LaVoie

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The synthesis and pharmacological activity of isoindolo[1,2-b]quinazolin-12(10H)-ones and isoindolo[2,1-a]benzimidazoles related to batracylin are described. The acute toxicity of batracyclin has been associated with the formation of its N-acetyl metabolite which is a potent inducer of unscheduled DNA synthesis in rat hepatocytes. The desamino derivative and the 8-aza analog of batracylin retained the ability to inhibit topoisomerase II but did not induce unscheduled DNA synthesis. While less active than batracylin, these analogs were cytotoxic to CCRF CEM leukemia cells. The isoindolo[2,1-a]benzimidazole derivatives were inactive as topoisomerase II inhibitors and, in general, failed to exhibit comparable antitumor activity or to induce unscheduled DNA synthesis.

Original languageEnglish
Pages (from-to)3434-3439
Number of pages6
JournalJournal of Medicinal Chemistry
Volume37
Issue number20
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

batracylin
Quinazolinones
Antineoplastic Agents
Pharmacology
Derivatives
DNA
Benzimidazoles
Topoisomerase II Inhibitors
Type II DNA Topoisomerase
Hepatocytes
Leukemia
Metabolites
Toxicity
Rats
benzimidazole

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Meegalla, S. K., Stevens, G. J., McQueen, C. A., Chen, A. Y., Yu, C., Liu, L. F., ... LaVoie, E. J. (1994). Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin. Journal of Medicinal Chemistry, 37(20), 3434-3439.

Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin. / Meegalla, Sanath K.; Stevens, Gregory J.; McQueen, Charlene A.; Chen, Allan Y.; Yu, Chiang; Liu, Leroy F.; Liu, Leroy-Fong; LaVoie, Edmond J.

In: Journal of Medicinal Chemistry, Vol. 37, No. 20, 1994, p. 3434-3439.

Research output: Contribution to journalArticle

Meegalla, Sanath K. ; Stevens, Gregory J. ; McQueen, Charlene A. ; Chen, Allan Y. ; Yu, Chiang ; Liu, Leroy F. ; Liu, Leroy-Fong ; LaVoie, Edmond J. / Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin. In: Journal of Medicinal Chemistry. 1994 ; Vol. 37, No. 20. pp. 3434-3439.
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