Synthesis and Integration of Virus-specific DNA in Cells Infected by RNA Tumor Viruses

H. E. Varmus, P. R. Shank, Hsing-Jien Kung

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

After infection of either permissive or nonpermissive cells by RNA tumor viruses, viral genetic information appears to persist indefinitely in the form of virus-specific, double-stranded DNA integrated covalently into the host chromosome (Varmus et al., 1975; Weinberg, 1977). In this report, we summarize our progress in deciphering the sequence of molecular events that culminates in the integration of viral DNA into the DNA of avian cells infected by avian sarcoma virus (ASV), and we offer our current view of the mechanisms involved.
Original languageEnglish
Title of host publicationIntegration and Excision of DNA Molecules
PublisherSpringer Berlin Heidelberg
Pages95-100
ISBN (Electronic)978-3-642-81203-3
ISBN (Print)978-3-642-81205-7
Publication statusPublished - 1978
Externally publishedYes

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    Varmus, H. E., Shank, P. R., & Kung, H-J. (1978). Synthesis and Integration of Virus-specific DNA in Cells Infected by RNA Tumor Viruses. In Integration and Excision of DNA Molecules (pp. 95-100). Springer Berlin Heidelberg. https://link.springer.com/chapter/10.1007%2F978-3-642-81203-3_13