Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives

Yi Ping Chin, Wei Jan Huang, Feng-Lin Hsu, Mei Hsiang Lin, Yuh Ling Lin

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

This study examines the synthesis and antibacterial activities of 5,7-dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their antibacterial activities against five microbial species such as E. coli, S. aureus, K. pneumonia, P. aeruginosa, and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus aureus with a MIC value of 2.5 μg/mL for each of the compounds.

Original languageEnglish
Pages (from-to)386-393
Number of pages8
JournalArchiv der Pharmazie
Volume344
Issue number6
DOIs
Publication statusPublished - Jun 2011

Keywords

  • 5,7-Dihydroxycoumarin
  • Antibacterial activity
  • Methicillin-resistance
  • Serratin

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

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