Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads

Fwu Long Mi, Hsing Wen Sung, Shin Shing Shyu, Chia Ching Su, Chih Kang Peng

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

Novel chitosan gel beads were synthesized by a coupled ionic and chemical co-crosslinking mechanism. Tripolyphosphate (TPP) and a naturally occurring crosslinking reagent, genipin, which has been used in herbal medicine, were employed, respectively, as an ionic and a chemical crosslinkers to prepare the chitosan-based networks of gel beads. The competitive crosslinking of chitosan with ionic crosslinker (TPP) and chemical crosslinker (genipin) was characterized by FTIR, UV and EDAX spectroscopy (X-ray energy dispersion) spectroscopy. The variation of characteristic peak of genipin observed from UV spectroscopy and the characteristic peak of tripolyphosphate in crosslinked chitosan-based networks observed from FTIR spectroscopy suggests that the co-crosslinking mechanism is dependent on the pH of TPP/genipin co-crosslinker. The energy profiles of carbon and phosphorus estimated from confirms that chemical crosslinking dominates the co-crosslinking reaction at higher pH condition (pH 7,0 and 9.0) and ionic crosslinking dominates the co-crosslinking reaction at lower pH condition (pH 1.0, 3.0 and 5.0). The pH-dependent ionic/chemical co-crosslinking mechanism shows an obvious effect on the swelling property and enzymatic degradation behavior of prepared chitosan networks. These results reveal that the ionic/chemical co-crosslinked chitosan networks may be suitable for biomedical applications.

Original languageEnglish
Pages (from-to)6521-6530
Number of pages10
JournalPolymer
Volume44
Issue number21
Publication statusPublished - Sep 18 2003
Externally publishedYes

Fingerprint

Chitosan
Crosslinking
Gels
Spectroscopy
Cross-Linking Reagents
triphosphoric acid
genipin
X ray spectroscopy
Ultraviolet spectroscopy
Phosphorus
Swelling
Energy dispersive spectroscopy
Carbon
Degradation

Keywords

  • Chitosan
  • Genipin
  • Tripolyphosphate

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

Cite this

Mi, F. L., Sung, H. W., Shyu, S. S., Su, C. C., & Peng, C. K. (2003). Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads. Polymer, 44(21), 6521-6530.

Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads. / Mi, Fwu Long; Sung, Hsing Wen; Shyu, Shin Shing; Su, Chia Ching; Peng, Chih Kang.

In: Polymer, Vol. 44, No. 21, 18.09.2003, p. 6521-6530.

Research output: Contribution to journalArticle

Mi, FL, Sung, HW, Shyu, SS, Su, CC & Peng, CK 2003, 'Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads', Polymer, vol. 44, no. 21, pp. 6521-6530.
Mi, Fwu Long ; Sung, Hsing Wen ; Shyu, Shin Shing ; Su, Chia Ching ; Peng, Chih Kang. / Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads. In: Polymer. 2003 ; Vol. 44, No. 21. pp. 6521-6530.
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