Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads

Fwu Long Mi, Hsing Wen Sung, Shin Shing Shyu, Chia Ching Su, Chih Kang Peng

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207 Citations (Scopus)

Abstract

Novel chitosan gel beads were synthesized by a coupled ionic and chemical co-crosslinking mechanism. Tripolyphosphate (TPP) and a naturally occurring crosslinking reagent, genipin, which has been used in herbal medicine, were employed, respectively, as an ionic and a chemical crosslinkers to prepare the chitosan-based networks of gel beads. The competitive crosslinking of chitosan with ionic crosslinker (TPP) and chemical crosslinker (genipin) was characterized by FTIR, UV and EDAX spectroscopy (X-ray energy dispersion) spectroscopy. The variation of characteristic peak of genipin observed from UV spectroscopy and the characteristic peak of tripolyphosphate in crosslinked chitosan-based networks observed from FTIR spectroscopy suggests that the co-crosslinking mechanism is dependent on the pH of TPP/genipin co-crosslinker. The energy profiles of carbon and phosphorus estimated from confirms that chemical crosslinking dominates the co-crosslinking reaction at higher pH condition (pH 7,0 and 9.0) and ionic crosslinking dominates the co-crosslinking reaction at lower pH condition (pH 1.0, 3.0 and 5.0). The pH-dependent ionic/chemical co-crosslinking mechanism shows an obvious effect on the swelling property and enzymatic degradation behavior of prepared chitosan networks. These results reveal that the ionic/chemical co-crosslinked chitosan networks may be suitable for biomedical applications.

Original languageEnglish
Pages (from-to)6521-6530
Number of pages10
JournalPolymer
Volume44
Issue number21
Publication statusPublished - Sep 18 2003
Externally publishedYes

Keywords

  • Chitosan
  • Genipin
  • Tripolyphosphate

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

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  • Cite this

    Mi, F. L., Sung, H. W., Shyu, S. S., Su, C. C., & Peng, C. K. (2003). Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads. Polymer, 44(21), 6521-6530.