Synthesis and biological evaluation of chalcones having heterosubstituent(s)

Sweety, S. Kumar, K. Nepali, S. Sapra, O. P. Suri, K. L. Dhar, G. S. Sarma, A. K. Saxena

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Chalcones and their synthetic analogues appear to have the same binding site of tubuline as phenstatin, combretastatin steganacin and podophylotoxin and are therefore capable to inhibit cancer cell proliferation. The phenyl rings with appropriate substitutions maintain a fixed distance between two centers of aryl rings. The two aromatic rings in these molecules are arranged like the two wings of a butterfly having certain dihedral angle between them, therefore a "butterfly model" is proposed an important structural feature responsible for their antitubulin activity. In this sequence a series of chalcones were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. In addition the synthetics reduced MIC of ciprofloxacin upto four fold this indicates their bioavailability enhancing potential.

Original languageEnglish
Pages (from-to)801-806
Number of pages6
JournalIndian Journal of Pharmaceutical Sciences
Volume72
Issue number6
DOIs
Publication statusPublished - Nov 1 2010

Keywords

  • Antimicrobial
  • chalcones
  • in vitro cytotoxicity

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Sweety, Kumar, S., Nepali, K., Sapra, S., Suri, O. P., Dhar, K. L., Sarma, G. S., & Saxena, A. K. (2010). Synthesis and biological evaluation of chalcones having heterosubstituent(s). Indian Journal of Pharmaceutical Sciences, 72(6), 801-806. https://doi.org/10.4103/0250-474X.84602