Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Jang-Yang Chang, Mei-Jung Lai, Yi-Ting Chang, Hsueh Yun Lee, Yun-Ching Cheng, Ching-Chuan Kuo, Min-Chieh Su, Chi-Yen Chang, Jing Ping Liou

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A series of 7-arylindoline-1-benzenesulfonamides were prepared and evaluated for anticancer activity. 7-(4′-Cyanophenyl)indoline-1- benzenesulfonamide 15 exhibited substantial antiproliferative activity with IC50 values ranging from 17-32 nM against a variety of human cancer cell lines, including MDR resistant line. Compound 15 (IC50 = 1.5 μM) also showed more potent inhibition of tubulin polymerization than 4a (combretastatin A-4, IC50 = 2.0 μM) and displayed strong binding to the colchicine binding site of the tubulin.

Original languageEnglish
Pages (from-to)152-155
Number of pages4
JournalMedChemComm
Volume1
Issue number2
DOIs
Publication statusPublished - Aug 2010

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

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