TY - JOUR
T1 - Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents
AU - Hsieh, Cheng Chih
AU - Lee, Hsueh Yun
AU - Nien, Chih Ying
AU - Kuo, Ching Chuan
AU - Chang, Chi Yen
AU - Chang, Jang Yang
AU - Liou, Jing Ping
PY - 2011/3
Y1 - 2011/3
N2 - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.
AB - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.
KW - Antiproliferative activity
KW - Combretastatin analogs
KW - Multidrug-resistant
KW - Trimethoxyquinolines
UR - http://www.scopus.com/inward/record.url?scp=79953115506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953115506&partnerID=8YFLogxK
U2 - 10.3390/molecules16032274
DO - 10.3390/molecules16032274
M3 - Article
C2 - 21383664
AN - SCOPUS:79953115506
SN - 1420-3049
VL - 16
SP - 2274
EP - 2284
JO - Molecules
JF - Molecules
IS - 3
ER -
