Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh, Hsueh Yun Lee, Chih Ying Nien, Ching Chuan Kuo, Chi Yen Chang, Jang Yang Chang, Jing Ping Liou

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

Original languageEnglish
Pages (from-to)2274-2284
Number of pages11
JournalMolecules
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Antiproliferative activity
  • Combretastatin analogs
  • Multidrug-resistant
  • Trimethoxyquinolines

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents'. Together they form a unique fingerprint.

Cite this