Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.
|Number of pages||6|
|Journal||International Journal of Peptide and Protein Research|
|Publication status||Published - Jan 1 1979|
- disulfide bridges
- opiate activity
ASJC Scopus subject areas