SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

JAMES BLAKE, WEN‐CHANG ‐C CHANG, CHOH HAO LI

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalInternational Journal of Peptide and Protein Research
Volume14
Issue number3
DOIs
Publication statusPublished - Jan 1 1979
Externally publishedYes

Keywords

  • disulfide bridges
  • opiate activity
  • radioimmunoactivity
  • β‐endorphin

ASJC Scopus subject areas

  • Biochemistry

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