Synthesis and biological activity of AHMA-EDTA conjugates

Kamesh Rastogi, Ting Chao Chou, Chun Yuan Ting, Kuo Tung Chen, Jaulang Hwang, Tsann Long Su

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.

Original languageEnglish
Pages (from-to)278-292
Number of pages15
JournalMedicinal Chemistry Research
Volume11
Issue number5
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Bioactivity
Edetic Acid
Type II DNA Topoisomerase
DNA Cleavage
Butyric Acid
Hydrocarbons
Antineoplastic Agents
Glycine
gamma-Aminobutyric Acid
DNA

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery

Cite this

Rastogi, K., Chou, T. C., Ting, C. Y., Chen, K. T., Hwang, J., & Su, T. L. (2002). Synthesis and biological activity of AHMA-EDTA conjugates. Medicinal Chemistry Research, 11(5), 278-292.

Synthesis and biological activity of AHMA-EDTA conjugates. / Rastogi, Kamesh; Chou, Ting Chao; Ting, Chun Yuan; Chen, Kuo Tung; Hwang, Jaulang; Su, Tsann Long.

In: Medicinal Chemistry Research, Vol. 11, No. 5, 2002, p. 278-292.

Research output: Contribution to journalArticle

Rastogi, K, Chou, TC, Ting, CY, Chen, KT, Hwang, J & Su, TL 2002, 'Synthesis and biological activity of AHMA-EDTA conjugates', Medicinal Chemistry Research, vol. 11, no. 5, pp. 278-292.
Rastogi K, Chou TC, Ting CY, Chen KT, Hwang J, Su TL. Synthesis and biological activity of AHMA-EDTA conjugates. Medicinal Chemistry Research. 2002;11(5):278-292.
Rastogi, Kamesh ; Chou, Ting Chao ; Ting, Chun Yuan ; Chen, Kuo Tung ; Hwang, Jaulang ; Su, Tsann Long. / Synthesis and biological activity of AHMA-EDTA conjugates. In: Medicinal Chemistry Research. 2002 ; Vol. 11, No. 5. pp. 278-292.
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