Abstract
Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.
| Original language | English |
|---|---|
| Pages (from-to) | 278-292 |
| Number of pages | 15 |
| Journal | Medicinal Chemistry Research |
| Volume | 11 |
| Issue number | 5 |
| Publication status | Published - 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery
Cite this
Rastogi, K., Chou, T. C., Ting, C. Y., Chen, K. T., Hwang, J., & Su, T. L. (2002). Synthesis and biological activity of AHMA-EDTA conjugates. Medicinal Chemistry Research, 11(5), 278-292.