Synthesis and biological activity of AHMA-EDTA conjugates

Kamesh Rastogi, Ting Chao Chou, Chun Yuan Ting, Kuo Tung Chen, Jaulang Hwang, Tsann Long Su

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.

Original languageEnglish
Pages (from-to)278-292
Number of pages15
JournalMedicinal Chemistry Research
Volume11
Issue number5
Publication statusPublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery

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