Abstract
Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.
| Original language | English |
|---|---|
| Pages (from-to) | 278-292 |
| Number of pages | 15 |
| Journal | Medicinal Chemistry Research |
| Volume | 11 |
| Issue number | 5 |
| Publication status | Published - 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery
Cite this
Synthesis and biological activity of AHMA-EDTA conjugates. / Rastogi, Kamesh; Chou, Ting Chao; Ting, Chun Yuan; Chen, Kuo Tung; Hwang, Jaulang; Su, Tsann Long.
In: Medicinal Chemistry Research, Vol. 11, No. 5, 2002, p. 278-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological activity of AHMA-EDTA conjugates
AU - Rastogi, Kamesh
AU - Chou, Ting Chao
AU - Ting, Chun Yuan
AU - Chen, Kuo Tung
AU - Hwang, Jaulang
AU - Su, Tsann Long
PY - 2002
Y1 - 2002
N2 - Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.
AB - Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.
UR - http://www.scopus.com/inward/record.url?scp=0036976317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036976317&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0036976317
VL - 11
SP - 278
EP - 292
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
SN - 1054-2523
IS - 5
ER -