Abstract
Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.
Original language | English |
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Pages (from-to) | 278-292 |
Number of pages | 15 |
Journal | Medicinal Chemistry Research |
Volume | 11 |
Issue number | 5 |
Publication status | Published - 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery