Synthesis and biological activity of AHMA-EDTA conjugates

Kamesh Rastogi; Ting Chao Chou; Chun Yuan Ting; Kuo Tung Chen; Jaulang Hwang; Tsann Long Su

Synthesis and biological activity of AHMA-EDTA conjugates

Kamesh Rastogi, Ting Chao Chou, Chun Yuan Ting, Kuo Tung Chen, Jaulang Hwang, Tsann Long Su

Research output: Contribution to journal › Article › peer-review

Abstract

Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.

Original language	English
Pages (from-to)	278-292
Number of pages	15
Journal	Medicinal Chemistry Research
Volume	11
Issue number	5
Publication status	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery

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title = "Synthesis and biological activity of AHMA-EDTA conjugates",

abstract = "Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.",

author = "Kamesh Rastogi and Chou, {Ting Chao} and Ting, {Chun Yuan} and Chen, {Kuo Tung} and Jaulang Hwang and Su, {Tsann Long}",

year = "2002",

language = "English",

volume = "11",

pages = "278--292",

journal = "Medicinal Chemistry Research",

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publisher = "Birkhause Boston",

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T1 - Synthesis and biological activity of AHMA-EDTA conjugates

AU - Rastogi, Kamesh

AU - Chou, Ting Chao

AU - Ting, Chun Yuan

AU - Chen, Kuo Tung

AU - Hwang, Jaulang

AU - Su, Tsann Long

PY - 2002

Y1 - 2002

N2 - Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.

AB - Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.

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EP - 292

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

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