Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine

Sheng Tung Huang, Jian Sheng Liao, Hsu Wei Fang, Chun Mao Lin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We designed and prepared the new C60 fullerene hybrids bearing a xanthine moiety as potential double-action anti-inflammatory agents, capable of simultaneous inhibition of LPS-induced NO and TNF-α production. The 10 μM of fulleropyrrolidine-xanthine dyad 2a and b were effective in suppressing LPS-induced NO production by 55.1 ± 2.1% and 58.6 ± 2.6%, respectively, but only 2b was also effectively in suppressing LPS-induced TNF-α production by 34.0 ± 2.7%. We believed that the agents synthesized herein would hold promise for future development of a new generation of potent anti-inflammatory agents.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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Keywords

  • Anti-inflammation
  • C fulleropyrrolidine
  • Nitric oxide
  • TNF-α
  • Xanthine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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