Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang, Shwu Jiuan Lin, Tsang Hsiung Yang, Kuo Hsiung Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

Original languageEnglish
Pages (from-to)941-944
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number8
DOIs
Publication statusPublished - Apr 23 1996

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Lignans
Transesterification
Structure-Activity Relationship
Lipase
Antiviral Agents
HIV-1
HIV
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans. / Yang, Li Ming; Lin, Shwu Jiuan; Yang, Tsang Hsiung; Lee, Kuo Hsiung.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 8, 23.04.1996, p. 941-944.

Research output: Contribution to journalArticle

Yang, Li Ming ; Lin, Shwu Jiuan ; Yang, Tsang Hsiung ; Lee, Kuo Hsiung. / Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 8. pp. 941-944.
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