SYNTAX score of infarct-related artery other than the number of coronary balloon inflations and deflations as an independent predictor of contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction

Cheng Wei Liu, Pen Chih Liao, Kuo Chin Chen, Jung Cheng Hsu, Chung Ming Tu, Yen Wen Wu, Ai Hsien Li, Shin Rong Ke, Jiunn-Lee Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Although remote ischemic post-conditioning (RIPC) has been shown to prevent contrast-induced acute kidney injury (CIAKI) in patients with acute coronary syndrome, its efficacy in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We examined the relationship among balloon inflations and deflations (BID) times, SYNTAX score of infarction-related artery (SI), periprocedural complications, and CIAKI in STEMI patients undergoing primary percutaneous coronary intervention (pPCI). Methods: Patients with STEMI undergoing pPCI with Mehran risk score (MRS) ≥ 5 were enrolled between February 2007 and September 2012. The study end point was the development of CIAKI. Results: Of 206 patients, the median age was 65 years [interquartile range (IQR): 55-77] with 72.8% male and Mehran risk score (MRS) 8 (IQR: 6-12). Receiver operating characteristic curve showed that BID times > 9 times or SI > 10was the best cut-off associated with CIAKI. In univariate analysis, significant associationwith CIAKI existed in BID > 9 times [odds ratio (OR): 3.106, 95% confidence interval (CI): 1.284-7.513, p = 0.012] and SI > 10 (OR: 3.909, 95% CI: 1.570-9.735, p = 0.003). Other variables associated with CIAKI included creatinine, hemoglobin, angiotensin converting enzyme inhibitor or angiotensin receptor blocker use at discharge. In multivariate analysis, SI > 10 remained an independent predictor of CIAKI in different adjustment model, even on top of MRS (adjusted OR: 3.498, 95% CI: 1.086-11.268, p = 0.036). Conclusions: Vascular complexity of infarct-related artery rather than higher BID times (> 9) was the major determinant of the development of CIAKI after pPCI in STEMI patients.

Original languageEnglish
Pages (from-to)362-376
Number of pages15
JournalActa Cardiologica Sinica
Volume33
Issue number4
DOIs
Publication statusPublished - Jul 1 2017
Externally publishedYes

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Economic Inflation
Acute Kidney Injury
Arteries
Percutaneous Coronary Intervention
Odds Ratio
Confidence Intervals
Ischemic Postconditioning
ST Elevation Myocardial Infarction
Angiotensin Receptor Antagonists
Acute Coronary Syndrome
Angiotensin-Converting Enzyme Inhibitors
ROC Curve
Infarction
Blood Vessels
Creatinine
Hemoglobins
Multivariate Analysis

Keywords

  • Acute kidney injury
  • Acute myocardial infarction
  • Primary percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

SYNTAX score of infarct-related artery other than the number of coronary balloon inflations and deflations as an independent predictor of contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction. / Liu, Cheng Wei; Liao, Pen Chih; Chen, Kuo Chin; Hsu, Jung Cheng; Tu, Chung Ming; Wu, Yen Wen; Li, Ai Hsien; Ke, Shin Rong; Lin, Jiunn-Lee.

In: Acta Cardiologica Sinica, Vol. 33, No. 4, 01.07.2017, p. 362-376.

Research output: Contribution to journalArticle

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abstract = "Background: Although remote ischemic post-conditioning (RIPC) has been shown to prevent contrast-induced acute kidney injury (CIAKI) in patients with acute coronary syndrome, its efficacy in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We examined the relationship among balloon inflations and deflations (BID) times, SYNTAX score of infarction-related artery (SI), periprocedural complications, and CIAKI in STEMI patients undergoing primary percutaneous coronary intervention (pPCI). Methods: Patients with STEMI undergoing pPCI with Mehran risk score (MRS) ≥ 5 were enrolled between February 2007 and September 2012. The study end point was the development of CIAKI. Results: Of 206 patients, the median age was 65 years [interquartile range (IQR): 55-77] with 72.8{\%} male and Mehran risk score (MRS) 8 (IQR: 6-12). Receiver operating characteristic curve showed that BID times > 9 times or SI > 10was the best cut-off associated with CIAKI. In univariate analysis, significant associationwith CIAKI existed in BID > 9 times [odds ratio (OR): 3.106, 95{\%} confidence interval (CI): 1.284-7.513, p = 0.012] and SI > 10 (OR: 3.909, 95{\%} CI: 1.570-9.735, p = 0.003). Other variables associated with CIAKI included creatinine, hemoglobin, angiotensin converting enzyme inhibitor or angiotensin receptor blocker use at discharge. In multivariate analysis, SI > 10 remained an independent predictor of CIAKI in different adjustment model, even on top of MRS (adjusted OR: 3.498, 95{\%} CI: 1.086-11.268, p = 0.036). Conclusions: Vascular complexity of infarct-related artery rather than higher BID times (> 9) was the major determinant of the development of CIAKI after pPCI in STEMI patients.",
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T1 - SYNTAX score of infarct-related artery other than the number of coronary balloon inflations and deflations as an independent predictor of contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction

AU - Liu, Cheng Wei

AU - Liao, Pen Chih

AU - Chen, Kuo Chin

AU - Hsu, Jung Cheng

AU - Tu, Chung Ming

AU - Wu, Yen Wen

AU - Li, Ai Hsien

AU - Ke, Shin Rong

AU - Lin, Jiunn-Lee

PY - 2017/7/1

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N2 - Background: Although remote ischemic post-conditioning (RIPC) has been shown to prevent contrast-induced acute kidney injury (CIAKI) in patients with acute coronary syndrome, its efficacy in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We examined the relationship among balloon inflations and deflations (BID) times, SYNTAX score of infarction-related artery (SI), periprocedural complications, and CIAKI in STEMI patients undergoing primary percutaneous coronary intervention (pPCI). Methods: Patients with STEMI undergoing pPCI with Mehran risk score (MRS) ≥ 5 were enrolled between February 2007 and September 2012. The study end point was the development of CIAKI. Results: Of 206 patients, the median age was 65 years [interquartile range (IQR): 55-77] with 72.8% male and Mehran risk score (MRS) 8 (IQR: 6-12). Receiver operating characteristic curve showed that BID times > 9 times or SI > 10was the best cut-off associated with CIAKI. In univariate analysis, significant associationwith CIAKI existed in BID > 9 times [odds ratio (OR): 3.106, 95% confidence interval (CI): 1.284-7.513, p = 0.012] and SI > 10 (OR: 3.909, 95% CI: 1.570-9.735, p = 0.003). Other variables associated with CIAKI included creatinine, hemoglobin, angiotensin converting enzyme inhibitor or angiotensin receptor blocker use at discharge. In multivariate analysis, SI > 10 remained an independent predictor of CIAKI in different adjustment model, even on top of MRS (adjusted OR: 3.498, 95% CI: 1.086-11.268, p = 0.036). Conclusions: Vascular complexity of infarct-related artery rather than higher BID times (> 9) was the major determinant of the development of CIAKI after pPCI in STEMI patients.

AB - Background: Although remote ischemic post-conditioning (RIPC) has been shown to prevent contrast-induced acute kidney injury (CIAKI) in patients with acute coronary syndrome, its efficacy in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We examined the relationship among balloon inflations and deflations (BID) times, SYNTAX score of infarction-related artery (SI), periprocedural complications, and CIAKI in STEMI patients undergoing primary percutaneous coronary intervention (pPCI). Methods: Patients with STEMI undergoing pPCI with Mehran risk score (MRS) ≥ 5 were enrolled between February 2007 and September 2012. The study end point was the development of CIAKI. Results: Of 206 patients, the median age was 65 years [interquartile range (IQR): 55-77] with 72.8% male and Mehran risk score (MRS) 8 (IQR: 6-12). Receiver operating characteristic curve showed that BID times > 9 times or SI > 10was the best cut-off associated with CIAKI. In univariate analysis, significant associationwith CIAKI existed in BID > 9 times [odds ratio (OR): 3.106, 95% confidence interval (CI): 1.284-7.513, p = 0.012] and SI > 10 (OR: 3.909, 95% CI: 1.570-9.735, p = 0.003). Other variables associated with CIAKI included creatinine, hemoglobin, angiotensin converting enzyme inhibitor or angiotensin receptor blocker use at discharge. In multivariate analysis, SI > 10 remained an independent predictor of CIAKI in different adjustment model, even on top of MRS (adjusted OR: 3.498, 95% CI: 1.086-11.268, p = 0.036). Conclusions: Vascular complexity of infarct-related artery rather than higher BID times (> 9) was the major determinant of the development of CIAKI after pPCI in STEMI patients.

KW - Acute kidney injury

KW - Acute myocardial infarction

KW - Primary percutaneous coronary intervention

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