Abstract

BACKGROUND: Osteopontin (OPN) is recognized as a potent immunoregulator of autoimmune disease. In the study, we tried to explore the association of serum OPN levels with autoimmune thyroid disease, including Graves' disease and Hashimoto's thyroiditis (HT), in an ethnic Chinese population.

METHODS: We enrolled 131 patients with GD, 33 patients with HT, and 123 healthy controls. Serum OPN, B-cell activating factor (BAFF), and interferon (IFN)-α levels were quantified. GD patients with high thyroid function at the time of sample collection were defined as having active GD, while the other patients were defined as having inactive GD.

RESULTS: Serum OPN levels were higher in active GD than in inactive GD and the control groups (p = 0.001 and p = 0.018, respectively). In GD, significant associations of OPN levels with thyroid-stimulating hormone receptor antibody (TSHRAb) levels were observed in women (r = -0.344, p = 0.002, and r = 0.440, p = 0.004, respectively) but not in men. OPN levels were associated with BAFF levels only in women with GD or HT (r = 0.506, p < 0.001 and r = 0.430, p = 0.025, respectively), but not in men with GD or HT.

CONCLUSIONS: Serum OPN levels were upregulated in active GD, and serum OPN levels were associated with thyroid function and TSHRAb levels in GD. Additionally, OPN levels were correlated with BAFF levels in GD and HT. The associations of OPN levels with clinical phenotypes of GD and BAFF levels showed a dimorphic pattern. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)e13122
JournalEuropean Journal of Clinical Investigation
DOIs
Publication statusE-pub ahead of print - Apr 29 2019

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Osteopontin
Thyroid Diseases
Autoimmune Diseases
Hashimoto Disease
Serum
Thyrotropin Receptors
Thyroid Gland
B-Cell Activating Factor
Antibodies
Graves Disease
Interferons
Phenotype
Control Groups

Cite this

Synchronized expressions of serum OPN and BAFF in autoimmune thyroid disease. / Cheng, Chao-Wen; Tang, Kam-Tsun; Fang, Wen-Fang; Lin, Jiunn-Diann.

In: European Journal of Clinical Investigation, 29.04.2019, p. e13122.

Research output: Contribution to journalArticle

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title = "Synchronized expressions of serum OPN and BAFF in autoimmune thyroid disease",
abstract = "BACKGROUND: Osteopontin (OPN) is recognized as a potent immunoregulator of autoimmune disease. In the study, we tried to explore the association of serum OPN levels with autoimmune thyroid disease, including Graves' disease and Hashimoto's thyroiditis (HT), in an ethnic Chinese population.METHODS: We enrolled 131 patients with GD, 33 patients with HT, and 123 healthy controls. Serum OPN, B-cell activating factor (BAFF), and interferon (IFN)-α levels were quantified. GD patients with high thyroid function at the time of sample collection were defined as having active GD, while the other patients were defined as having inactive GD.RESULTS: Serum OPN levels were higher in active GD than in inactive GD and the control groups (p = 0.001 and p = 0.018, respectively). In GD, significant associations of OPN levels with thyroid-stimulating hormone receptor antibody (TSHRAb) levels were observed in women (r = -0.344, p = 0.002, and r = 0.440, p = 0.004, respectively) but not in men. OPN levels were associated with BAFF levels only in women with GD or HT (r = 0.506, p < 0.001 and r = 0.430, p = 0.025, respectively), but not in men with GD or HT.CONCLUSIONS: Serum OPN levels were upregulated in active GD, and serum OPN levels were associated with thyroid function and TSHRAb levels in GD. Additionally, OPN levels were correlated with BAFF levels in GD and HT. The associations of OPN levels with clinical phenotypes of GD and BAFF levels showed a dimorphic pattern. This article is protected by copyright. All rights reserved.",
author = "Chao-Wen Cheng and Kam-Tsun Tang and Wen-Fang Fang and Jiunn-Diann Lin",
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year = "2019",
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journal = "European Journal of Clinical Investigation",
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T1 - Synchronized expressions of serum OPN and BAFF in autoimmune thyroid disease

AU - Cheng, Chao-Wen

AU - Tang, Kam-Tsun

AU - Fang, Wen-Fang

AU - Lin, Jiunn-Diann

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/4/29

Y1 - 2019/4/29

N2 - BACKGROUND: Osteopontin (OPN) is recognized as a potent immunoregulator of autoimmune disease. In the study, we tried to explore the association of serum OPN levels with autoimmune thyroid disease, including Graves' disease and Hashimoto's thyroiditis (HT), in an ethnic Chinese population.METHODS: We enrolled 131 patients with GD, 33 patients with HT, and 123 healthy controls. Serum OPN, B-cell activating factor (BAFF), and interferon (IFN)-α levels were quantified. GD patients with high thyroid function at the time of sample collection were defined as having active GD, while the other patients were defined as having inactive GD.RESULTS: Serum OPN levels were higher in active GD than in inactive GD and the control groups (p = 0.001 and p = 0.018, respectively). In GD, significant associations of OPN levels with thyroid-stimulating hormone receptor antibody (TSHRAb) levels were observed in women (r = -0.344, p = 0.002, and r = 0.440, p = 0.004, respectively) but not in men. OPN levels were associated with BAFF levels only in women with GD or HT (r = 0.506, p < 0.001 and r = 0.430, p = 0.025, respectively), but not in men with GD or HT.CONCLUSIONS: Serum OPN levels were upregulated in active GD, and serum OPN levels were associated with thyroid function and TSHRAb levels in GD. Additionally, OPN levels were correlated with BAFF levels in GD and HT. The associations of OPN levels with clinical phenotypes of GD and BAFF levels showed a dimorphic pattern. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: Osteopontin (OPN) is recognized as a potent immunoregulator of autoimmune disease. In the study, we tried to explore the association of serum OPN levels with autoimmune thyroid disease, including Graves' disease and Hashimoto's thyroiditis (HT), in an ethnic Chinese population.METHODS: We enrolled 131 patients with GD, 33 patients with HT, and 123 healthy controls. Serum OPN, B-cell activating factor (BAFF), and interferon (IFN)-α levels were quantified. GD patients with high thyroid function at the time of sample collection were defined as having active GD, while the other patients were defined as having inactive GD.RESULTS: Serum OPN levels were higher in active GD than in inactive GD and the control groups (p = 0.001 and p = 0.018, respectively). In GD, significant associations of OPN levels with thyroid-stimulating hormone receptor antibody (TSHRAb) levels were observed in women (r = -0.344, p = 0.002, and r = 0.440, p = 0.004, respectively) but not in men. OPN levels were associated with BAFF levels only in women with GD or HT (r = 0.506, p < 0.001 and r = 0.430, p = 0.025, respectively), but not in men with GD or HT.CONCLUSIONS: Serum OPN levels were upregulated in active GD, and serum OPN levels were associated with thyroid function and TSHRAb levels in GD. Additionally, OPN levels were correlated with BAFF levels in GD and HT. The associations of OPN levels with clinical phenotypes of GD and BAFF levels showed a dimorphic pattern. This article is protected by copyright. All rights reserved.

U2 - 10.1111/eci.13122

DO - 10.1111/eci.13122

M3 - Article

SP - e13122

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

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