Abstract
We aimed to investigate functional connectivity and variability across multiple frequency bands in brain networks underlying cognitive deficits in primary-progressive multiple sclerosis (PP-MS) and to explore how they are affected by the presence of cortical lesions (CLs). We analyzed functional connectivity and variability (measured as the standard deviation of BOLD signal amplitude) in resting state networks (RSNs) associated with cognitive deficits in different frequency bands in 25 PP-MS patients (12 M, mean age 50.9 ± 10.5 years) and 20 healthy subjects (9 M, mean age 51.0 ± 9.8 years). We confirmed the presence of a widespread cognitive deterioration in PP-MS patients, with main involvement of visuo-spatial and executive domains. Cognitively impaired patients showed increased variability, reduced synchronicity between networks involved in the control of cognitive macro-domains and hyper-synchronicity limited to the connections between networks functionally more segregated. CL volume was higher in patients with cognitive impairment and was correlated with functional connectivity and variability. We demonstrate, from the first time, that a functional reorganization characterized by hypo-synchronicity of functionally-related/hyper-synchronicity of functionally-segregated large scale networks and an abnormal pattern of neural activity underlie cognitive dysfunction in PP-MS, and that CLs possibly play a role in variability and functional connectivity abnormalities.
| Original language | English |
|---|---|
| Article number | 46411 |
| Journal | Scientific Reports |
| Volume | 7 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
| Externally published | Yes |
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Synchronization and variability imbalance underlie cognitive impairment in primary-progressive multiple sclerosis. / Petracca, Maria; Saiote, Catarina; Bender, Heidi A.; Arias, Franchesca; Farrell, Colleen; Magioncalda, Paola; Martino, Matteo; Miller, Aaron; Northoff, Georg; Lublin, Fred; Inglese, Matilde.
In: Scientific Reports, Vol. 7, 46411, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synchronization and variability imbalance underlie cognitive impairment in primary-progressive multiple sclerosis
AU - Petracca, Maria
AU - Saiote, Catarina
AU - Bender, Heidi A.
AU - Arias, Franchesca
AU - Farrell, Colleen
AU - Magioncalda, Paola
AU - Martino, Matteo
AU - Miller, Aaron
AU - Northoff, Georg
AU - Lublin, Fred
AU - Inglese, Matilde
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We aimed to investigate functional connectivity and variability across multiple frequency bands in brain networks underlying cognitive deficits in primary-progressive multiple sclerosis (PP-MS) and to explore how they are affected by the presence of cortical lesions (CLs). We analyzed functional connectivity and variability (measured as the standard deviation of BOLD signal amplitude) in resting state networks (RSNs) associated with cognitive deficits in different frequency bands in 25 PP-MS patients (12 M, mean age 50.9 ± 10.5 years) and 20 healthy subjects (9 M, mean age 51.0 ± 9.8 years). We confirmed the presence of a widespread cognitive deterioration in PP-MS patients, with main involvement of visuo-spatial and executive domains. Cognitively impaired patients showed increased variability, reduced synchronicity between networks involved in the control of cognitive macro-domains and hyper-synchronicity limited to the connections between networks functionally more segregated. CL volume was higher in patients with cognitive impairment and was correlated with functional connectivity and variability. We demonstrate, from the first time, that a functional reorganization characterized by hypo-synchronicity of functionally-related/hyper-synchronicity of functionally-segregated large scale networks and an abnormal pattern of neural activity underlie cognitive dysfunction in PP-MS, and that CLs possibly play a role in variability and functional connectivity abnormalities.
AB - We aimed to investigate functional connectivity and variability across multiple frequency bands in brain networks underlying cognitive deficits in primary-progressive multiple sclerosis (PP-MS) and to explore how they are affected by the presence of cortical lesions (CLs). We analyzed functional connectivity and variability (measured as the standard deviation of BOLD signal amplitude) in resting state networks (RSNs) associated with cognitive deficits in different frequency bands in 25 PP-MS patients (12 M, mean age 50.9 ± 10.5 years) and 20 healthy subjects (9 M, mean age 51.0 ± 9.8 years). We confirmed the presence of a widespread cognitive deterioration in PP-MS patients, with main involvement of visuo-spatial and executive domains. Cognitively impaired patients showed increased variability, reduced synchronicity between networks involved in the control of cognitive macro-domains and hyper-synchronicity limited to the connections between networks functionally more segregated. CL volume was higher in patients with cognitive impairment and was correlated with functional connectivity and variability. We demonstrate, from the first time, that a functional reorganization characterized by hypo-synchronicity of functionally-related/hyper-synchronicity of functionally-segregated large scale networks and an abnormal pattern of neural activity underlie cognitive dysfunction in PP-MS, and that CLs possibly play a role in variability and functional connectivity abnormalities.
UR - http://www.scopus.com/inward/record.url?scp=85033580329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033580329&partnerID=8YFLogxK
U2 - 10.1038/srep46411
DO - 10.1038/srep46411
M3 - Article
AN - SCOPUS:85033580329
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 46411
ER -