Abstract
Chitosan microspheres containing oxytetracycline (OTC), an antibiotic agent, were prepared by spray hardening and interfacial acylation methods. The object of this study was to prepare oxytetracycline-containing microspheres for oral administration and injection using different molecular weight (Mw 70,000 ~ 2,000,000) of chitosan. By the spray hardening method, microspheres with particle sizes between 5 and 30 μm could be obtained and might be suitable for intramuscular injection. On the other hand, chitosan microspheres with the ability to extend the dissolution period of oxytetracycline in low pH medium were also prepared by the interfacial acylation method. The result indicated that the releasing of oxytetracycline from various acylated chitosan microspheres was decreased with increasing the molecular weight of chitosan and would show well sustained-release property. Besides, the morphology of various microspheres and crystalline form transition of oxytetracycline were also studied using electron scanning microscope and X-ray analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 577-591 |
| Number of pages | 15 |
| Journal | Journal of Microencapsulation |
| Volume | 14 |
| Issue number | 5 |
| Publication status | Published - Sep 1997 |
| Externally published | Yes |
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Keywords
- Antibiotic agent
- Chitosan
- Interfacial acylation
- Microspheres
- Oxytetracycline
- Spray hardening
ASJC Scopus subject areas
- Chemistry (miscellaneous)
- Pharmaceutical Science
- Chemical Engineering(all)
- Pharmacology
Cite this
Sustained-release of oxytetracycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods. / Fwu-Long, Mi; Wong, Tsung Bi; Shyu, Shin Shing.
In: Journal of Microencapsulation, Vol. 14, No. 5, 09.1997, p. 577-591.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sustained-release of oxytetracycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods
AU - Fwu-Long, Mi
AU - Wong, Tsung Bi
AU - Shyu, Shin Shing
PY - 1997/9
Y1 - 1997/9
N2 - Chitosan microspheres containing oxytetracycline (OTC), an antibiotic agent, were prepared by spray hardening and interfacial acylation methods. The object of this study was to prepare oxytetracycline-containing microspheres for oral administration and injection using different molecular weight (Mw 70,000 ~ 2,000,000) of chitosan. By the spray hardening method, microspheres with particle sizes between 5 and 30 μm could be obtained and might be suitable for intramuscular injection. On the other hand, chitosan microspheres with the ability to extend the dissolution period of oxytetracycline in low pH medium were also prepared by the interfacial acylation method. The result indicated that the releasing of oxytetracycline from various acylated chitosan microspheres was decreased with increasing the molecular weight of chitosan and would show well sustained-release property. Besides, the morphology of various microspheres and crystalline form transition of oxytetracycline were also studied using electron scanning microscope and X-ray analysis.
AB - Chitosan microspheres containing oxytetracycline (OTC), an antibiotic agent, were prepared by spray hardening and interfacial acylation methods. The object of this study was to prepare oxytetracycline-containing microspheres for oral administration and injection using different molecular weight (Mw 70,000 ~ 2,000,000) of chitosan. By the spray hardening method, microspheres with particle sizes between 5 and 30 μm could be obtained and might be suitable for intramuscular injection. On the other hand, chitosan microspheres with the ability to extend the dissolution period of oxytetracycline in low pH medium were also prepared by the interfacial acylation method. The result indicated that the releasing of oxytetracycline from various acylated chitosan microspheres was decreased with increasing the molecular weight of chitosan and would show well sustained-release property. Besides, the morphology of various microspheres and crystalline form transition of oxytetracycline were also studied using electron scanning microscope and X-ray analysis.
KW - Antibiotic agent
KW - Chitosan
KW - Interfacial acylation
KW - Microspheres
KW - Oxytetracycline
KW - Spray hardening
UR - http://www.scopus.com/inward/record.url?scp=15644383204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=15644383204&partnerID=8YFLogxK
M3 - Article
VL - 14
SP - 577
EP - 591
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
SN - 0265-2048
IS - 5
ER -