Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network

Tze Wen Chung, Shyr Yi Lin, Der Zen Liu, Yu Chang Tyan, Juin Sen Yang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study investigates in vitro the drug delivery characteristics of new thermo-sensitive gels, P-CS/GA gels, in which a chitosan (CS) network is crosslinked with various concentrations of glutaraldehyde (GA) that interpenetrates Poloxamer (P) gels. The results indicate that the swelling ratios of all P-CS/GA gels are markedly superior to those of non-swelling P and P-CS gels. For example, P-CS/GA (0.1 wt.%) gels have swelling ratios of 13.2 ± 1.0, which are maintained for approximately 18 h in water at 37 °C. In vitro releases of 5-FU from P-CS/GA (0.1 wt.%) gels had significantly lower initial burst release (P <0.01) and lasted much longer than those from gels without a CS network. For example, the duration of release of 5-FU was in a significantly sustained manner for up to 52 h, which was about 10 times or longer than the period of delivery using P or P-CS gels. The release of drugs from gels with an interpenetrating CS network could be modeled by Fickian diffusion; the characteristic constant 'k' of drug-gel systems decreased as increasing GA concentrations in the P-CS/GA gels, and increasing the viscosities of the P, P-CS and P-CS/GA solutions.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume382
Issue number1-2
DOIs
Publication statusPublished - Dec 1 2009

Fingerprint

Poloxamer
Chitosan
Fluorouracil
Gels
Glutaral
Viscosity
Pharmaceutical Preparations

Keywords

  • 5-FU
  • Drug delivery
  • Hydrogels
  • Interpenetrating CS network
  • Poloxamer

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network. / Chung, Tze Wen; Lin, Shyr Yi; Liu, Der Zen; Tyan, Yu Chang; Yang, Juin Sen.

In: International Journal of Pharmaceutics, Vol. 382, No. 1-2, 01.12.2009, p. 39-44.

Research output: Contribution to journalArticle

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