Sustained-release effect of codried excipients of microcrystalline cellulose and Ganoderma fiber

W. T. Ke, H. O. Ho, T. Tsai, M. T. Sheu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The sustained-release effects of codried excipient of modified Ganoderma (treated with alkaline solution) and microcrystalline cellulose at different ratios were examined using acetaminophen (ACT) as a model drug. Results demonstrate that the crushing strength of most ACT tablets made with codried powder at all ratios increased as compaction force increased; but a rapid decline was observed when compression force exceeded 2 tons. Drug release from tablets compressed at 0.5 ton increased as modified Ganoderma fiber content increased. But when the compression force exceeded 1 ton, the release rate was not influenced by the compaction force or the increasing content of Ganoderma fiber. However, the dissolution of ACT from these tablets could be sustained for longer than 24 h. The extent of drug release was shown to increase with increasing amounts of modified Ganoderma in the codried excipient. The addition of disintegrants could further accelerate the drug release from the tablet. Drug release was also dependent upon the amount and kind of disintegrant used. The influence was in the following order: primojel > crospovidone > starch 1500.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume51
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Ganoderma
Excipients
Tablets
Acetaminophen
Povidone
Starch
Powders
Drug Liberation
microcrystalline cellulose
Pharmaceutical Preparations

Keywords

  • Acetaminophen
  • Ganoderma
  • Microcrystalline cellulose
  • Sustained release

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

Cite this

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title = "Sustained-release effect of codried excipients of microcrystalline cellulose and Ganoderma fiber",
abstract = "The sustained-release effects of codried excipient of modified Ganoderma (treated with alkaline solution) and microcrystalline cellulose at different ratios were examined using acetaminophen (ACT) as a model drug. Results demonstrate that the crushing strength of most ACT tablets made with codried powder at all ratios increased as compaction force increased; but a rapid decline was observed when compression force exceeded 2 tons. Drug release from tablets compressed at 0.5 ton increased as modified Ganoderma fiber content increased. But when the compression force exceeded 1 ton, the release rate was not influenced by the compaction force or the increasing content of Ganoderma fiber. However, the dissolution of ACT from these tablets could be sustained for longer than 24 h. The extent of drug release was shown to increase with increasing amounts of modified Ganoderma in the codried excipient. The addition of disintegrants could further accelerate the drug release from the tablet. Drug release was also dependent upon the amount and kind of disintegrant used. The influence was in the following order: primojel > crospovidone > starch 1500.",
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author = "Ke, {W. T.} and Ho, {H. O.} and T. Tsai and Sheu, {M. T.}",
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TY - JOUR

T1 - Sustained-release effect of codried excipients of microcrystalline cellulose and Ganoderma fiber

AU - Ke, W. T.

AU - Ho, H. O.

AU - Tsai, T.

AU - Sheu, M. T.

PY - 2001

Y1 - 2001

N2 - The sustained-release effects of codried excipient of modified Ganoderma (treated with alkaline solution) and microcrystalline cellulose at different ratios were examined using acetaminophen (ACT) as a model drug. Results demonstrate that the crushing strength of most ACT tablets made with codried powder at all ratios increased as compaction force increased; but a rapid decline was observed when compression force exceeded 2 tons. Drug release from tablets compressed at 0.5 ton increased as modified Ganoderma fiber content increased. But when the compression force exceeded 1 ton, the release rate was not influenced by the compaction force or the increasing content of Ganoderma fiber. However, the dissolution of ACT from these tablets could be sustained for longer than 24 h. The extent of drug release was shown to increase with increasing amounts of modified Ganoderma in the codried excipient. The addition of disintegrants could further accelerate the drug release from the tablet. Drug release was also dependent upon the amount and kind of disintegrant used. The influence was in the following order: primojel > crospovidone > starch 1500.

AB - The sustained-release effects of codried excipient of modified Ganoderma (treated with alkaline solution) and microcrystalline cellulose at different ratios were examined using acetaminophen (ACT) as a model drug. Results demonstrate that the crushing strength of most ACT tablets made with codried powder at all ratios increased as compaction force increased; but a rapid decline was observed when compression force exceeded 2 tons. Drug release from tablets compressed at 0.5 ton increased as modified Ganoderma fiber content increased. But when the compression force exceeded 1 ton, the release rate was not influenced by the compaction force or the increasing content of Ganoderma fiber. However, the dissolution of ACT from these tablets could be sustained for longer than 24 h. The extent of drug release was shown to increase with increasing amounts of modified Ganoderma in the codried excipient. The addition of disintegrants could further accelerate the drug release from the tablet. Drug release was also dependent upon the amount and kind of disintegrant used. The influence was in the following order: primojel > crospovidone > starch 1500.

KW - Acetaminophen

KW - Ganoderma

KW - Microcrystalline cellulose

KW - Sustained release

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