Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension

Yung Hsin Cheng, Kuo Hsuan Hung, Tung Hu Tsai, Chia Jung Lee, Ruy Yu Ku, Allen Wen Hsiang Chiu, Shih Hwa Chiou, Catherine Jui Ling Liu

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Glaucoma is an irreversible ocular disease that may lead to progressive visual field loss and eventually to blindness with inadequately controlled intraocular pressure (IOP). Latanoprost is one of the most potent ocular hypotensive compounds, the current first-line therapy in glaucoma. However, the daily instillation required for efficacy and undesirable side-effects are major causes of treatment adherence failure and persistence in glaucoma therapy. In the present study, we developed an injectable thermosensitive chitosan/gelatin/glycerol phosphate (C/G/GP) hydrogel as a sustained-release system of latanoprost for glaucoma treatment. The latanoprost-loaded C/G/GP hydrogel can gel within 1 min at 37 °C. The results show a sustained release of latanoprost from C/G/GP hydrogel in vitro and in vivo. The latanoprost-loaded C/G/GP hydrogel showed a good in vitro and in vivo biocompatibility. A rabbit model of glaucoma was established by intravitreal injection of triamcinolone acetonide. After a single subconjunctival injection of latanoprost-loaded C/G/GP hydrogel, IOP was significantly decreased within 8 days and then remained at a normal level. The results of the study suggest that latanoprost-loaded C/G/GP hydrogel may have a potential application in glaucoma therapy.

Original languageEnglish
Pages (from-to)4360-4366
Number of pages7
JournalActa Biomaterialia
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 1 2014
Externally publishedYes

Keywords

  • Drug delivery
  • Glaucoma
  • Hydrogel
  • Latanoprost

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Medicine(all)

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