Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas

Hung Hsu Hung, Yi You Chiou, Cheng Yuan Hsia, Chien Wei Su, Yi Hong Chou, Jen Huey Chiang, Wei Yu Kao, Teh Ia Huo, Yi Hsiang Huang, Yu Hui Su, Han Chieh Lin, Shou Dong Lee, Jaw Ching Wu

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Abstract

Background & Aims: Differences in efficacy of radiofrequency ablation (RFA) and surgical resection (SR) are not clear for patients with hepatocellular carcinoma (HCC). Methods: From 2002 to 2007, 419 patients with HCCs ≤5 cm were enrolled consecutively in the study. Among these patients, 190 and 229 patients received RFA and SR, respectively, as their first treatment. Factors were analyzed in terms of overall survival and recurrence by multivariate analysis and propensity score matching analysis. Results: The SR group had younger age, a higher male-to-female ratio, higher prevalence of hepatitis B virus, lower prevalence of hepatitis C virus, better liver function reserve, and larger tumor size than the RFA group. The cumulative 5-year overall survival rates were 79.3% in the SR group and 67.4% in the RFA group. During the follow-up period, tumors recurred in 244 patients in a median time of 14.5 ± 15.7 months. Before propensity-score matching, the RFA group had shorter overall survival time (P = .009) and higher tumor recurrence rate (P < .001) than the SR group. After matching, RFA was comparable to SR in overall survival time (P = .519), but the RFA group still had a greater incidence of tumor recurrence (P < .001). In patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC, RFA was as effective as SR for overall survival time and recurrence. Conclusions: Patients with small HCCs have a higher rate of tumor recurrence following RFA than surgery, but overall survival rates are comparable between therapies. RFA is as effective as surgery in patients with BCLC stage 0 HCC.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalClinical Gastroenterology and Hepatology
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2011
Externally publishedYes

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Hepatocellular Carcinoma
Survival Rate
Recurrence
Propensity Score
Survival
Neoplasms
Liver Neoplasms
Hepatitis B virus
Hepacivirus
Multivariate Analysis
Liver
Incidence
Therapeutics

Keywords

  • Hepatic
  • Liver Surgery
  • Liver Tumor

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas. / Hung, Hung Hsu; Chiou, Yi You; Hsia, Cheng Yuan; Su, Chien Wei; Chou, Yi Hong; Chiang, Jen Huey; Kao, Wei Yu; Huo, Teh Ia; Huang, Yi Hsiang; Su, Yu Hui; Lin, Han Chieh; Lee, Shou Dong; Wu, Jaw Ching.

In: Clinical Gastroenterology and Hepatology, Vol. 9, No. 1, 01.01.2011, p. 79-86.

Research output: Contribution to journalArticle

Hung, HH, Chiou, YY, Hsia, CY, Su, CW, Chou, YH, Chiang, JH, Kao, WY, Huo, TI, Huang, YH, Su, YH, Lin, HC, Lee, SD & Wu, JC 2011, 'Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas', Clinical Gastroenterology and Hepatology, vol. 9, no. 1, pp. 79-86. https://doi.org/10.1016/j.cgh.2010.08.018
Hung, Hung Hsu ; Chiou, Yi You ; Hsia, Cheng Yuan ; Su, Chien Wei ; Chou, Yi Hong ; Chiang, Jen Huey ; Kao, Wei Yu ; Huo, Teh Ia ; Huang, Yi Hsiang ; Su, Yu Hui ; Lin, Han Chieh ; Lee, Shou Dong ; Wu, Jaw Ching. / Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas. In: Clinical Gastroenterology and Hepatology. 2011 ; Vol. 9, No. 1. pp. 79-86.
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T1 - Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas

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AU - Chiou, Yi You

AU - Hsia, Cheng Yuan

AU - Su, Chien Wei

AU - Chou, Yi Hong

AU - Chiang, Jen Huey

AU - Kao, Wei Yu

AU - Huo, Teh Ia

AU - Huang, Yi Hsiang

AU - Su, Yu Hui

AU - Lin, Han Chieh

AU - Lee, Shou Dong

AU - Wu, Jaw Ching

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N2 - Background & Aims: Differences in efficacy of radiofrequency ablation (RFA) and surgical resection (SR) are not clear for patients with hepatocellular carcinoma (HCC). Methods: From 2002 to 2007, 419 patients with HCCs ≤5 cm were enrolled consecutively in the study. Among these patients, 190 and 229 patients received RFA and SR, respectively, as their first treatment. Factors were analyzed in terms of overall survival and recurrence by multivariate analysis and propensity score matching analysis. Results: The SR group had younger age, a higher male-to-female ratio, higher prevalence of hepatitis B virus, lower prevalence of hepatitis C virus, better liver function reserve, and larger tumor size than the RFA group. The cumulative 5-year overall survival rates were 79.3% in the SR group and 67.4% in the RFA group. During the follow-up period, tumors recurred in 244 patients in a median time of 14.5 ± 15.7 months. Before propensity-score matching, the RFA group had shorter overall survival time (P = .009) and higher tumor recurrence rate (P < .001) than the SR group. After matching, RFA was comparable to SR in overall survival time (P = .519), but the RFA group still had a greater incidence of tumor recurrence (P < .001). In patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC, RFA was as effective as SR for overall survival time and recurrence. Conclusions: Patients with small HCCs have a higher rate of tumor recurrence following RFA than surgery, but overall survival rates are comparable between therapies. RFA is as effective as surgery in patients with BCLC stage 0 HCC.

AB - Background & Aims: Differences in efficacy of radiofrequency ablation (RFA) and surgical resection (SR) are not clear for patients with hepatocellular carcinoma (HCC). Methods: From 2002 to 2007, 419 patients with HCCs ≤5 cm were enrolled consecutively in the study. Among these patients, 190 and 229 patients received RFA and SR, respectively, as their first treatment. Factors were analyzed in terms of overall survival and recurrence by multivariate analysis and propensity score matching analysis. Results: The SR group had younger age, a higher male-to-female ratio, higher prevalence of hepatitis B virus, lower prevalence of hepatitis C virus, better liver function reserve, and larger tumor size than the RFA group. The cumulative 5-year overall survival rates were 79.3% in the SR group and 67.4% in the RFA group. During the follow-up period, tumors recurred in 244 patients in a median time of 14.5 ± 15.7 months. Before propensity-score matching, the RFA group had shorter overall survival time (P = .009) and higher tumor recurrence rate (P < .001) than the SR group. After matching, RFA was comparable to SR in overall survival time (P = .519), but the RFA group still had a greater incidence of tumor recurrence (P < .001). In patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC, RFA was as effective as SR for overall survival time and recurrence. Conclusions: Patients with small HCCs have a higher rate of tumor recurrence following RFA than surgery, but overall survival rates are comparable between therapies. RFA is as effective as surgery in patients with BCLC stage 0 HCC.

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