Survival predictors in patients with node-negative gastric carcinoma

Chin Chun Lee, Chew Wun Wu, Su Shun Lo, Jen Hao Chen, Anna F.Y. Li, Mao-Chih Hsieh, King Han Shen, Wing Yiu Lui

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Presence or absence of nodal metastasis influences outcome of gastric cancer patients. This study gives insight into survival predictors and clinicopathological features of node-negative gastric adenocarcinoma. Methods: Between 1988 and 1999, 689 gastric cancer patients without other cancer or gastrectomy for benign disease who underwent curative resection were enrolled in this study. Clinicopathological data in patients with node metastasis were compared with those without. Results: The survival rate at 5 and 10 years for node-negative cases was 91.7% and 89.7%, respectively. On univariate analysis, node-negative patients were characterized by frequent location in the lower two-thirds of the stomach (84.9%), tumor size less than 4 cm (63.5%), grossly superficial type (71.6%), more medullary stromal reaction (50.5%) and intestinal type (67.7%), tumor invasion confined to serosa (78.4%), less poorly differentiated cell type (43.2%), and less lymphovascular invasion (33.4%). Multivariate analysis demonstrated that lymphovascular invasion (relative risk: 5.036) and depth of cancer invasion (relative risk: 4.404) were independent poor prognostic factors. However, lymphovascular invasion and serosal invasion were also correlated (P < 0.001). Conclusion: Patients with node-negative gastric adenocarcinoma had less disease progression and a favorable survival. Lymphovascular invasion and depth of cancer invasion were two independent but correlated survival predictors.

Original languageEnglish
Pages (from-to)1014-1018
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume22
Issue number7
DOIs
Publication statusPublished - Jan 1 2007
Externally publishedYes

Keywords

  • Gastric cancer
  • Lymph node metastasis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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