Surgical treatment of mediastinal neurogenic tumors in adults

A 10-year experience

Fu C. Fang, Shih Chun Lee, Ching Tzao, Hung Chang, Yeung Leung Cheng, Hsian H. Hsu, Jen Chih Chen

Research output: Contribution to journalArticle

Abstract

Background: Neurogenic tumors are often observed in the paravertebral sulcus. They are generally benign in adults and are good candidates for resection by video-assisted thoracic surgery (VATS). We review our series of thoracic neurogenic tumors, focusing on their surgical management. Methods: The medical charts of 25 patients with mediastinal neurogenic tumors, treated from September 1997 to January 2008, were reviewed regarding the radiographic presentation, histopathology, and surgical treatment of these tumors. Results: The patients included 16 men and nine women (mean age, 41 years; range, 20-65 years). Seventeen patients were pathologically diagnosed with schwannomas, three with neurofibromas, and five with ganglioneuromas. The median tumor size was 6.2 cm (range, 1.9-15 cm). The tumors were located in the paravertebral sulcus in 19 patients, chest wall in five patients, and visceral compartment in one patient. Seventeen patients (68%) underwent resection via standard thoracotomy, whereas the remaining were resected with VATS, including one with robotic VATS. The postoperative hospital stay was shorter in patients treated with VATS than in those treated with thoracotomy. There were no tumor-related deaths or recurrence during follow-up. Conclusion: As expected, the most frequent mediastinal neurogenic tumor was schwannoma originating from the sympathetic chains. Infrequently, tumors may arise from the vagus nerve in the visceral compartment of the mediastinum or from an intercostal nerve if they are located at sites distant from the mediastinum. VATS is a good alternative for mediastinal neurogenic tumors smaller than 5 cm or that preoperatively lack features of intraspinal extension.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalJournal of Medical Sciences (Taiwan)
Volume28
Issue number4
Publication statusPublished - Aug 2008
Externally publishedYes

Fingerprint

antineoplaston A10
Video-Assisted Thoracic Surgery
Neoplasms
Therapeutics
Neurilemmoma
Mediastinum
Thoracotomy
Intercostal Nerves
Ganglioneuroma
Neurofibroma
Vagus Nerve
Robotics
Thoracic Wall
Length of Stay
Thorax
Recurrence

Keywords

  • Mediastinum
  • Neurogenic tumor
  • VATS

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fang, F. C., Lee, S. C., Tzao, C., Chang, H., Cheng, Y. L., Hsu, H. H., & Chen, J. C. (2008). Surgical treatment of mediastinal neurogenic tumors in adults: A 10-year experience. Journal of Medical Sciences (Taiwan), 28(4), 155-158.

Surgical treatment of mediastinal neurogenic tumors in adults : A 10-year experience. / Fang, Fu C.; Lee, Shih Chun; Tzao, Ching; Chang, Hung; Cheng, Yeung Leung; Hsu, Hsian H.; Chen, Jen Chih.

In: Journal of Medical Sciences (Taiwan), Vol. 28, No. 4, 08.2008, p. 155-158.

Research output: Contribution to journalArticle

Fang, FC, Lee, SC, Tzao, C, Chang, H, Cheng, YL, Hsu, HH & Chen, JC 2008, 'Surgical treatment of mediastinal neurogenic tumors in adults: A 10-year experience', Journal of Medical Sciences (Taiwan), vol. 28, no. 4, pp. 155-158.
Fang, Fu C. ; Lee, Shih Chun ; Tzao, Ching ; Chang, Hung ; Cheng, Yeung Leung ; Hsu, Hsian H. ; Chen, Jen Chih. / Surgical treatment of mediastinal neurogenic tumors in adults : A 10-year experience. In: Journal of Medical Sciences (Taiwan). 2008 ; Vol. 28, No. 4. pp. 155-158.
@article{4ec96717f7334a508e43b41eb63615e8,
title = "Surgical treatment of mediastinal neurogenic tumors in adults: A 10-year experience",
abstract = "Background: Neurogenic tumors are often observed in the paravertebral sulcus. They are generally benign in adults and are good candidates for resection by video-assisted thoracic surgery (VATS). We review our series of thoracic neurogenic tumors, focusing on their surgical management. Methods: The medical charts of 25 patients with mediastinal neurogenic tumors, treated from September 1997 to January 2008, were reviewed regarding the radiographic presentation, histopathology, and surgical treatment of these tumors. Results: The patients included 16 men and nine women (mean age, 41 years; range, 20-65 years). Seventeen patients were pathologically diagnosed with schwannomas, three with neurofibromas, and five with ganglioneuromas. The median tumor size was 6.2 cm (range, 1.9-15 cm). The tumors were located in the paravertebral sulcus in 19 patients, chest wall in five patients, and visceral compartment in one patient. Seventeen patients (68{\%}) underwent resection via standard thoracotomy, whereas the remaining were resected with VATS, including one with robotic VATS. The postoperative hospital stay was shorter in patients treated with VATS than in those treated with thoracotomy. There were no tumor-related deaths or recurrence during follow-up. Conclusion: As expected, the most frequent mediastinal neurogenic tumor was schwannoma originating from the sympathetic chains. Infrequently, tumors may arise from the vagus nerve in the visceral compartment of the mediastinum or from an intercostal nerve if they are located at sites distant from the mediastinum. VATS is a good alternative for mediastinal neurogenic tumors smaller than 5 cm or that preoperatively lack features of intraspinal extension.",
keywords = "Mediastinum, Neurogenic tumor, VATS",
author = "Fang, {Fu C.} and Lee, {Shih Chun} and Ching Tzao and Hung Chang and Cheng, {Yeung Leung} and Hsu, {Hsian H.} and Chen, {Jen Chih}",
year = "2008",
month = "8",
language = "English",
volume = "28",
pages = "155--158",
journal = "Journal of Medical Sciences",
issn = "1011-4564",
publisher = "國防醫學院",
number = "4",

}

TY - JOUR

T1 - Surgical treatment of mediastinal neurogenic tumors in adults

T2 - A 10-year experience

AU - Fang, Fu C.

AU - Lee, Shih Chun

AU - Tzao, Ching

AU - Chang, Hung

AU - Cheng, Yeung Leung

AU - Hsu, Hsian H.

AU - Chen, Jen Chih

PY - 2008/8

Y1 - 2008/8

N2 - Background: Neurogenic tumors are often observed in the paravertebral sulcus. They are generally benign in adults and are good candidates for resection by video-assisted thoracic surgery (VATS). We review our series of thoracic neurogenic tumors, focusing on their surgical management. Methods: The medical charts of 25 patients with mediastinal neurogenic tumors, treated from September 1997 to January 2008, were reviewed regarding the radiographic presentation, histopathology, and surgical treatment of these tumors. Results: The patients included 16 men and nine women (mean age, 41 years; range, 20-65 years). Seventeen patients were pathologically diagnosed with schwannomas, three with neurofibromas, and five with ganglioneuromas. The median tumor size was 6.2 cm (range, 1.9-15 cm). The tumors were located in the paravertebral sulcus in 19 patients, chest wall in five patients, and visceral compartment in one patient. Seventeen patients (68%) underwent resection via standard thoracotomy, whereas the remaining were resected with VATS, including one with robotic VATS. The postoperative hospital stay was shorter in patients treated with VATS than in those treated with thoracotomy. There were no tumor-related deaths or recurrence during follow-up. Conclusion: As expected, the most frequent mediastinal neurogenic tumor was schwannoma originating from the sympathetic chains. Infrequently, tumors may arise from the vagus nerve in the visceral compartment of the mediastinum or from an intercostal nerve if they are located at sites distant from the mediastinum. VATS is a good alternative for mediastinal neurogenic tumors smaller than 5 cm or that preoperatively lack features of intraspinal extension.

AB - Background: Neurogenic tumors are often observed in the paravertebral sulcus. They are generally benign in adults and are good candidates for resection by video-assisted thoracic surgery (VATS). We review our series of thoracic neurogenic tumors, focusing on their surgical management. Methods: The medical charts of 25 patients with mediastinal neurogenic tumors, treated from September 1997 to January 2008, were reviewed regarding the radiographic presentation, histopathology, and surgical treatment of these tumors. Results: The patients included 16 men and nine women (mean age, 41 years; range, 20-65 years). Seventeen patients were pathologically diagnosed with schwannomas, three with neurofibromas, and five with ganglioneuromas. The median tumor size was 6.2 cm (range, 1.9-15 cm). The tumors were located in the paravertebral sulcus in 19 patients, chest wall in five patients, and visceral compartment in one patient. Seventeen patients (68%) underwent resection via standard thoracotomy, whereas the remaining were resected with VATS, including one with robotic VATS. The postoperative hospital stay was shorter in patients treated with VATS than in those treated with thoracotomy. There were no tumor-related deaths or recurrence during follow-up. Conclusion: As expected, the most frequent mediastinal neurogenic tumor was schwannoma originating from the sympathetic chains. Infrequently, tumors may arise from the vagus nerve in the visceral compartment of the mediastinum or from an intercostal nerve if they are located at sites distant from the mediastinum. VATS is a good alternative for mediastinal neurogenic tumors smaller than 5 cm or that preoperatively lack features of intraspinal extension.

KW - Mediastinum

KW - Neurogenic tumor

KW - VATS

UR - http://www.scopus.com/inward/record.url?scp=52649140601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52649140601&partnerID=8YFLogxK

M3 - Article

VL - 28

SP - 155

EP - 158

JO - Journal of Medical Sciences

JF - Journal of Medical Sciences

SN - 1011-4564

IS - 4

ER -