Abstract
Background/Aims: To report the results of surgical treatment of intrahepatic cholangiocarcinoma with different procedures and to find the factors that may affect the long-term survival. Materials and Methods: From 1987 to 1994, 57 patients with intrahepatic cholangiocarcinoma underwent laparotomy. Among them, resection was performed in 27 patients, operative drainage in 14 patients and biopsy only in 14 patients. The liver resections included 9 right lobectomies, 14 left lobectomies and 4 hilar resections. All specimens were stained with carcinoembryonic antigen (CEA) and HLA-DR monoclonal antibodies. Results: There were 7 postoperative mortalities, one in the resection group (1/27), true in the drainage group (2/14) and 4 in the biopsy group (4/14). Patients undergoing resection survived significantly longer (median, 8 months) (mean, 19 ± 4 months) than patients undergoing drainage (median, 4 months) (mean, 6 ± 2 months) and biopsy (median, 2 months) (mean, 3 ± 1 months) (p < 0.01). After resection, univariate analysis showed that positive hiliar lymphnode was a poor prognostic sign and mucobilia was a good prognostic sign. Age, sex, size of tumors cell differentiation, clear margin, and positive HLA-DR and CEA had no effect on prognosis. Conclusion: The results support the surgical resection of intrahepatic cholangiocarcinoma. Tumor free margin should be aggressively achieved but may not be necessary. Mucobilia is a good prognostic sign and positive hilar lymphnode is a grave sign.
| Original language | English |
|---|---|
| Pages (from-to) | 760-765 |
| Number of pages | 6 |
| Journal | Hepato-Gastroenterology |
| Volume | 44 |
| Issue number | 15 |
| Publication status | Published - Jul 17 1997 |
| Externally published | Yes |
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Keywords
- Cholangiocarcinoma
- HLA-DR
- Mucobilia
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Surgical treatment of cholangiocarcinoma. / Chou, Fong Fu; Sheen-Chen, Shyr Ming; Chen, Yaw Sen; Chen, Mao Chan; Chen, Chao Long.
In: Hepato-Gastroenterology, Vol. 44, No. 15, 17.07.1997, p. 760-765.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Surgical treatment of cholangiocarcinoma
AU - Chou, Fong Fu
AU - Sheen-Chen, Shyr Ming
AU - Chen, Yaw Sen
AU - Chen, Mao Chan
AU - Chen, Chao Long
PY - 1997/7/17
Y1 - 1997/7/17
N2 - Background/Aims: To report the results of surgical treatment of intrahepatic cholangiocarcinoma with different procedures and to find the factors that may affect the long-term survival. Materials and Methods: From 1987 to 1994, 57 patients with intrahepatic cholangiocarcinoma underwent laparotomy. Among them, resection was performed in 27 patients, operative drainage in 14 patients and biopsy only in 14 patients. The liver resections included 9 right lobectomies, 14 left lobectomies and 4 hilar resections. All specimens were stained with carcinoembryonic antigen (CEA) and HLA-DR monoclonal antibodies. Results: There were 7 postoperative mortalities, one in the resection group (1/27), true in the drainage group (2/14) and 4 in the biopsy group (4/14). Patients undergoing resection survived significantly longer (median, 8 months) (mean, 19 ± 4 months) than patients undergoing drainage (median, 4 months) (mean, 6 ± 2 months) and biopsy (median, 2 months) (mean, 3 ± 1 months) (p < 0.01). After resection, univariate analysis showed that positive hiliar lymphnode was a poor prognostic sign and mucobilia was a good prognostic sign. Age, sex, size of tumors cell differentiation, clear margin, and positive HLA-DR and CEA had no effect on prognosis. Conclusion: The results support the surgical resection of intrahepatic cholangiocarcinoma. Tumor free margin should be aggressively achieved but may not be necessary. Mucobilia is a good prognostic sign and positive hilar lymphnode is a grave sign.
AB - Background/Aims: To report the results of surgical treatment of intrahepatic cholangiocarcinoma with different procedures and to find the factors that may affect the long-term survival. Materials and Methods: From 1987 to 1994, 57 patients with intrahepatic cholangiocarcinoma underwent laparotomy. Among them, resection was performed in 27 patients, operative drainage in 14 patients and biopsy only in 14 patients. The liver resections included 9 right lobectomies, 14 left lobectomies and 4 hilar resections. All specimens were stained with carcinoembryonic antigen (CEA) and HLA-DR monoclonal antibodies. Results: There were 7 postoperative mortalities, one in the resection group (1/27), true in the drainage group (2/14) and 4 in the biopsy group (4/14). Patients undergoing resection survived significantly longer (median, 8 months) (mean, 19 ± 4 months) than patients undergoing drainage (median, 4 months) (mean, 6 ± 2 months) and biopsy (median, 2 months) (mean, 3 ± 1 months) (p < 0.01). After resection, univariate analysis showed that positive hiliar lymphnode was a poor prognostic sign and mucobilia was a good prognostic sign. Age, sex, size of tumors cell differentiation, clear margin, and positive HLA-DR and CEA had no effect on prognosis. Conclusion: The results support the surgical resection of intrahepatic cholangiocarcinoma. Tumor free margin should be aggressively achieved but may not be necessary. Mucobilia is a good prognostic sign and positive hilar lymphnode is a grave sign.
KW - Cholangiocarcinoma
KW - HLA-DR
KW - Mucobilia
UR - http://www.scopus.com/inward/record.url?scp=0030950274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030950274&partnerID=8YFLogxK
M3 - Article
C2 - 9222685
AN - SCOPUS:0030950274
VL - 44
SP - 760
EP - 765
JO - Acta hepato-splenologica
JF - Acta hepato-splenologica
SN - 0172-6390
IS - 15
ER -