Surgical treatment of cholangiocarcinoma

Fong Fu Chou, Shyr Ming Sheen-Chen, Yaw Sen Chen, Mao Chan Chen, Chao Long Chen

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background/Aims: To report the results of surgical treatment of intrahepatic cholangiocarcinoma with different procedures and to find the factors that may affect the long-term survival. Materials and Methods: From 1987 to 1994, 57 patients with intrahepatic cholangiocarcinoma underwent laparotomy. Among them, resection was performed in 27 patients, operative drainage in 14 patients and biopsy only in 14 patients. The liver resections included 9 right lobectomies, 14 left lobectomies and 4 hilar resections. All specimens were stained with carcinoembryonic antigen (CEA) and HLA-DR monoclonal antibodies. Results: There were 7 postoperative mortalities, one in the resection group (1/27), true in the drainage group (2/14) and 4 in the biopsy group (4/14). Patients undergoing resection survived significantly longer (median, 8 months) (mean, 19 ± 4 months) than patients undergoing drainage (median, 4 months) (mean, 6 ± 2 months) and biopsy (median, 2 months) (mean, 3 ± 1 months) (p < 0.01). After resection, univariate analysis showed that positive hiliar lymphnode was a poor prognostic sign and mucobilia was a good prognostic sign. Age, sex, size of tumors cell differentiation, clear margin, and positive HLA-DR and CEA had no effect on prognosis. Conclusion: The results support the surgical resection of intrahepatic cholangiocarcinoma. Tumor free margin should be aggressively achieved but may not be necessary. Mucobilia is a good prognostic sign and positive hilar lymphnode is a grave sign.

Original languageEnglish
Pages (from-to)760-765
Number of pages6
JournalHepato-Gastroenterology
Volume44
Issue number15
Publication statusPublished - Jul 17 1997
Externally publishedYes

Fingerprint

Cholangiocarcinoma
Drainage
Carcinoembryonic Antigen
HLA-DR Antigens
Biopsy
Therapeutics
Laparotomy
Cell Differentiation
Monoclonal Antibodies
Survival
Mortality
Liver
Neoplasms

Keywords

  • Cholangiocarcinoma
  • HLA-DR
  • Mucobilia

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Chou, F. F., Sheen-Chen, S. M., Chen, Y. S., Chen, M. C., & Chen, C. L. (1997). Surgical treatment of cholangiocarcinoma. Hepato-Gastroenterology, 44(15), 760-765.

Surgical treatment of cholangiocarcinoma. / Chou, Fong Fu; Sheen-Chen, Shyr Ming; Chen, Yaw Sen; Chen, Mao Chan; Chen, Chao Long.

In: Hepato-Gastroenterology, Vol. 44, No. 15, 17.07.1997, p. 760-765.

Research output: Contribution to journalArticle

Chou, FF, Sheen-Chen, SM, Chen, YS, Chen, MC & Chen, CL 1997, 'Surgical treatment of cholangiocarcinoma', Hepato-Gastroenterology, vol. 44, no. 15, pp. 760-765.
Chou FF, Sheen-Chen SM, Chen YS, Chen MC, Chen CL. Surgical treatment of cholangiocarcinoma. Hepato-Gastroenterology. 1997 Jul 17;44(15):760-765.
Chou, Fong Fu ; Sheen-Chen, Shyr Ming ; Chen, Yaw Sen ; Chen, Mao Chan ; Chen, Chao Long. / Surgical treatment of cholangiocarcinoma. In: Hepato-Gastroenterology. 1997 ; Vol. 44, No. 15. pp. 760-765.
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