Supratentorial cerebrospinal fluid production rate in healthy adults: Quantification with two-dimensional cine phase-contrast MR imaging with high temporal and spatial resolution

Teng Yi Huang, Hsiao Wen Chung, Ming Yen Chen, Lung Hui Giiang, Shy Chyi Chin, Chang Shin Lee, Cheng Yu Chen, Yi Jui Liu

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

A method for objectively determining supratentorial cerebrospinal fluid (CSF) production rate is described. The method employs cine phase-contrast magnetic resonance imaging with high temporal and spatial resolution at the level of the aqueduct of Sylvius. Automatic encircling of the aqueduct was accomplished by using a pulsatility-based segmentation approach. Results in 23 healthy adults (18 men, five women; age range, 21-39 years) yielded an average CSF production rate of 305 μL/min ± 145 (standard deviation); this rate is in good agreement with literature-reported values obtained with invasive ventriculolumbar perfusion measurements. Average operator imprecision was 23.1% if automatic segmentation was not used. The proposed method is potentially an effective means for measuring supratentorial CSF production rate in humans.

Original languageEnglish
Pages (from-to)603-608
Number of pages6
JournalRadiology
Volume233
Issue number2
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

Fingerprint

Cerebrospinal Fluid
Cerebral Aqueduct
Perfusion
Magnetic Resonance Imaging

Keywords

  • Cerebrospinal fluid, flow dynamics, 167.12144
  • Cerebrospinal fluid, MR, 167.12144
  • Magnetic resonance (MR), phase imaging, 163.12144

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Supratentorial cerebrospinal fluid production rate in healthy adults : Quantification with two-dimensional cine phase-contrast MR imaging with high temporal and spatial resolution. / Huang, Teng Yi; Chung, Hsiao Wen; Chen, Ming Yen; Giiang, Lung Hui; Chin, Shy Chyi; Lee, Chang Shin; Chen, Cheng Yu; Liu, Yi Jui.

In: Radiology, Vol. 233, No. 2, 11.2004, p. 603-608.

Research output: Contribution to journalArticle

Huang, Teng Yi ; Chung, Hsiao Wen ; Chen, Ming Yen ; Giiang, Lung Hui ; Chin, Shy Chyi ; Lee, Chang Shin ; Chen, Cheng Yu ; Liu, Yi Jui. / Supratentorial cerebrospinal fluid production rate in healthy adults : Quantification with two-dimensional cine phase-contrast MR imaging with high temporal and spatial resolution. In: Radiology. 2004 ; Vol. 233, No. 2. pp. 603-608.
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