Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells

Medicine & Life Sciences

• 1-nitropyrene 100%
• Benzo(a)pyrene 70%
• Hep G2 Cells 60%
• Cytochrome P-450 Enzyme System 55%
• benzo(a)pyrene-DNA adduct 35%
• Proteins 21%
• Proteolysis 14%
• Polycyclic Aromatic Hydrocarbons 13%
• Reactive Oxygen Species 8%
• Dithiothreitol 6%
• Protein Stability 6%
• Messenger RNA 5%
• RNA Stability 5%
• Northern Blotting 5%
• Hepatocellular Carcinoma 4%
• Antioxidants 3%
• Western Blotting 3%
• Cell Line 3%
• DNA 2%
• In Vitro Techniques 2%

Chemical Compounds

• 1-Nitropyrene 90%
• Cytochrome P450 61%
• Protein 23%
• Protein Hydrolysis 11%
• Adduct 11%
• Reactive Oxygen Metabolite 9%
• Arene 8%
• Genotoxicity 6%
• Benzo[a]pyrene 5%
• Mixture 4%
• Antioxidant Agent 3%