Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

Medicine & Life Sciences

• 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine 8%
• A549 Cells 18%
• Acetylcysteine 12%
• Apoptosis 34%
• Caspase 9 12%
• dihydromyricetin 100%
• Extracellular Signal-Regulated MAP Kinases 60%
• Flavonoids 5%
• JNK Mitogen-Activated Protein Kinases 63%
• Mitochondrial Membrane Potential 5%
• Mitochondrial Membranes 6%
• Mitogen-Activated Protein Kinase 1 6%
• Mitogen-Activated Protein Kinase 3 6%
• Mitogen-Activated Protein Kinase 8 8%
• Mitogen-Activated Protein Kinase 9 8%
• Non-Small Cell Lung Carcinoma 50%
• Peroxides 7%
• Poly(ADP-ribose) Polymerases 13%
• Reactive Oxygen Species 45%

Chemical Compounds

• Cleavage 10%
• Depolarization 8%
• Dihydromyricetin 98%
• Dioxygen 27%
• Flavonoid 7%
• Flow 5%
• Membrane Potential 8%
• Peroxide 7%
• Phosphotransferase Inhibitor 10%
• Poly(ADPribose) 21%
• Reactive Oxygen Metabolite 7%

Earth & Environmental Sciences

• apoptosis 75%
• cell 34%
• cleavage 6%
• inhibitor 5%
• reactive oxygen species 67%