Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin

Thangirala Sudha, Murat Yalcin, Hung Yun Lin, Ahmed M. Elmetwally, Tipu Nazeer, Thiruvengadam Arumugam, Patricia Phillips, Shaker A. Mousa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Sulfated non-anticoagulant heparins (S-NACHs) might be preferred for potential clinical use in cancer patients without affecting hemostasis as compared to low molecular weight heparins (LMWHs). We investigated anti-tumor effects, anti-angiogenesis effects, and mechanisms of S-NACH in a mouse model of pancreatic cancer as compared to the LMWH tinzaparin. S-NACH or tinzaparin with or without gemcitabine were administered, and tumor luminescent signal intensity, tumor weight, and histopathology were assessed at the termination of the study. S-NACH and LMWH efficiently inhibited tumor growth and metastasis, without any observed bleeding events with S-NACH as compared to tinzaparin. S-NACH distinctly increased tumor necrosis and enhanced gemcitabine response in the mouse pancreatic cancer models. These data suggest the potential implication of S-NACH as a neoadjuvant in pancreatic cancer.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalCancer Letters
Volume350
Issue number1-2
DOIs
Publication statusPublished - Aug 1 2014

Keywords

  • Anti-cancer
  • Low molecular weight heparin
  • Non-anticoagulant heparin
  • Pancreatic cancer
  • Tumor suppressor
  • Tumor survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Sudha, T., Yalcin, M., Lin, H. Y., Elmetwally, A. M., Nazeer, T., Arumugam, T., Phillips, P., & Mousa, S. A. (2014). Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin. Cancer Letters, 350(1-2), 25-33. https://doi.org/10.1016/j.canlet.2014.04.016