Supplementation of probiotic Butyricicoccus pullicaecorum mediates anticancer effect on bladder urothelial cells by regulating butyrate-responsive molecular signatures

Yen Chieh Wang, Wei Chi Ku, Chih Yi Liu, Yu Che Cheng, Chih Cheng Chien, Kang Wei Chang, Chi Jung Huang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In bladder cancer, urothelial carcinoma is the most common histologic subtype, accounting for more than 90% of cases. Pathogenic effects due to the dysbiosis of gut microbiota are localized not only in the colon, but also in regulating bladder cancer distally. Butyrate, a short-chain fatty acid produced by gut microbial metabolism, is mainly studied in colon diseases. Therefore, the resolution of the anti-cancer effects of butyrate-producing microbes on bladder urothelial cells and knowledge of the butyrate-responsive molecules must have clinical significance. Here, we demonstrate a correlation between urothelial cancer of the bladder and Butyricicoccus pullicaecorum. This butyrate-producing microbe or their metabolite, butyrate, mediated anti-cancer effects on bladder urothelial cells by regulating cell cycle, cell growth, apoptosis, and gene expression. For example, a tumor suppressor against urothelial cancer of the bladder, bladder cancer-associated protein, was induced in butyrate-treated HT1376 cells, a human urinary bladder cancer cell line. In conclusion, urothelial cancer of the bladder is a significant health problem. To improve the health of bladder urothelial cells, supplementation of B. pullicaecorum may be necessary and can further regulate butyrate-responsive molecular signatures.

Original languageEnglish
Article number2270
JournalDiagnostics
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Apoptosis
  • Bladder cancer-associated protein
  • Butyrate
  • Butyricicoccus pullicaecorum
  • Urothelial bladder cancer

ASJC Scopus subject areas

  • Clinical Biochemistry

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