Supplementation comprising dietary fish oil with all-trans retinoic acid decreased blood lipids and fat accumulation in C57BL/6J mice

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Abstract

This study aimed to assess the effects of fish oil plus all-trans retinoic acid (ATRA) on lipid metabolism and fat accumulation. Forty male C57BL/6J mice were divided into four groups; the FO, SO, FR, and SR groups were provided with fish oil, soybean oil, fish oil with ATRA, and soybean oil with ATRA, respectively. After 16 weeks, the SR and FR groups had significantly lower body weight than the SO and FO groups. Moreover, the FR group had the lowest reproductive white adipose tissue weight, liver triglyceride level, and acetyl-CoA carboxylase activity and the highest acyl-CoA oxidase and catalase activities among all groups. Additionally, fish oil alone also showed significantly improved serum and liver lipid profiles. ATRA in combination with fish oil or soybean oil both had significantly decreased reproductive white adipose tissue and increased expression of liver peroxisome proliferator-activated receptor δ and retinoic acid receptor α. ATRA may inhibit weight gain and fat accumulation, thus preventing obesity.

Original languageEnglish
Pages (from-to)310-315
Number of pages6
JournalJournal of Functional Foods
Volume52
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Unsaturated Dietary Fats
Fish Oils
retinoic acid
Tretinoin
fish oils
Inbred C57BL Mouse
blood lipids
dietary supplements
Fats
Soybean Oil
Lipids
mice
lipids
White Adipose Tissue
soybean oil
white adipose tissue
Liver
liver
Acyl-CoA Oxidase
Acetyl-CoA Carboxylase

Keywords

  • All-trans retinoic acid
  • Fish oil
  • Obesity
  • PPARδ
  • Retinoic acid receptor

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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title = "Supplementation comprising dietary fish oil with all-trans retinoic acid decreased blood lipids and fat accumulation in C57BL/6J mice",
abstract = "This study aimed to assess the effects of fish oil plus all-trans retinoic acid (ATRA) on lipid metabolism and fat accumulation. Forty male C57BL/6J mice were divided into four groups; the FO, SO, FR, and SR groups were provided with fish oil, soybean oil, fish oil with ATRA, and soybean oil with ATRA, respectively. After 16 weeks, the SR and FR groups had significantly lower body weight than the SO and FO groups. Moreover, the FR group had the lowest reproductive white adipose tissue weight, liver triglyceride level, and acetyl-CoA carboxylase activity and the highest acyl-CoA oxidase and catalase activities among all groups. Additionally, fish oil alone also showed significantly improved serum and liver lipid profiles. ATRA in combination with fish oil or soybean oil both had significantly decreased reproductive white adipose tissue and increased expression of liver peroxisome proliferator-activated receptor δ and retinoic acid receptor α. ATRA may inhibit weight gain and fat accumulation, thus preventing obesity.",
keywords = "All-trans retinoic acid, Fish oil, Obesity, PPARδ, Retinoic acid receptor",
author = "Tung, {Yu Tang} and Lyu, {Kan Ni} and {Chun Chen}, Yi and Chien, {Yi Wen}",
year = "2019",
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doi = "10.1016/j.jff.2018.11.010",
language = "English",
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journal = "Journal of Functional Foods",
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T1 - Supplementation comprising dietary fish oil with all-trans retinoic acid decreased blood lipids and fat accumulation in C57BL/6J mice

AU - Tung, Yu Tang

AU - Lyu, Kan Ni

AU - Chun Chen, Yi

AU - Chien, Yi Wen

PY - 2019/1/1

Y1 - 2019/1/1

N2 - This study aimed to assess the effects of fish oil plus all-trans retinoic acid (ATRA) on lipid metabolism and fat accumulation. Forty male C57BL/6J mice were divided into four groups; the FO, SO, FR, and SR groups were provided with fish oil, soybean oil, fish oil with ATRA, and soybean oil with ATRA, respectively. After 16 weeks, the SR and FR groups had significantly lower body weight than the SO and FO groups. Moreover, the FR group had the lowest reproductive white adipose tissue weight, liver triglyceride level, and acetyl-CoA carboxylase activity and the highest acyl-CoA oxidase and catalase activities among all groups. Additionally, fish oil alone also showed significantly improved serum and liver lipid profiles. ATRA in combination with fish oil or soybean oil both had significantly decreased reproductive white adipose tissue and increased expression of liver peroxisome proliferator-activated receptor δ and retinoic acid receptor α. ATRA may inhibit weight gain and fat accumulation, thus preventing obesity.

AB - This study aimed to assess the effects of fish oil plus all-trans retinoic acid (ATRA) on lipid metabolism and fat accumulation. Forty male C57BL/6J mice were divided into four groups; the FO, SO, FR, and SR groups were provided with fish oil, soybean oil, fish oil with ATRA, and soybean oil with ATRA, respectively. After 16 weeks, the SR and FR groups had significantly lower body weight than the SO and FO groups. Moreover, the FR group had the lowest reproductive white adipose tissue weight, liver triglyceride level, and acetyl-CoA carboxylase activity and the highest acyl-CoA oxidase and catalase activities among all groups. Additionally, fish oil alone also showed significantly improved serum and liver lipid profiles. ATRA in combination with fish oil or soybean oil both had significantly decreased reproductive white adipose tissue and increased expression of liver peroxisome proliferator-activated receptor δ and retinoic acid receptor α. ATRA may inhibit weight gain and fat accumulation, thus preventing obesity.

KW - All-trans retinoic acid

KW - Fish oil

KW - Obesity

KW - PPARδ

KW - Retinoic acid receptor

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