Superoxide dismutases in human palatine tonsils

Ming Tang Lai, Takuya Ohmichi, Satoko Miyahara, Akitane Mori, Yu Masuda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In order to investigate the protective system of human palatine tonsils against the cytotoxic superoxide radicals (O2-) generated from the oxygen-related bactericidal system, immunohistochemistry and electron spin resonance (ESR) spectrometry were used to detect the distribution and activities of superoxide dismutases (SODs) in tonsils of different related systemic diseases. Immunohistochemistry showed that SODs distribute in extrafollicular lymphatic tissue and crypt epithelium. No distribution difference could be found between tonsils of different related systemic diseases. ESR revealed no significant difference between SODs activities in tonsils of different related systemic diseases. However, the mitochondrial SOD activity was found to constitute approximately 50%-60% of the total tonsillar cellular SODs activity. The results suggest: i) tonsils possess the ability to control cytotoxic O2-, ii) crypt epithelium and extrafollicular lymphatic tissue may encounter more O2- threat, iii) SODs may be important in protecting germinal centers from O2- injury, and iv) systemic diseases are less related to the local expression of tonsillar SODs.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalActa Oto-Laryngologica, Supplement
Issue number523
Publication statusPublished - 1996

Fingerprint

Palatine Tonsil
Superoxide Dismutase
Electron Spin Resonance Spectroscopy
Lymphoid Tissue
Epithelium
Immunohistochemistry
Germinal Center
Superoxides
Spectrum Analysis
Oxygen
Wounds and Injuries

Keywords

  • Palatine tonsil
  • Superoxide dismutases
  • Superoxide radical

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Lai, M. T., Ohmichi, T., Miyahara, S., Mori, A., & Masuda, Y. (1996). Superoxide dismutases in human palatine tonsils. Acta Oto-Laryngologica, Supplement, (523), 120-123.

Superoxide dismutases in human palatine tonsils. / Lai, Ming Tang; Ohmichi, Takuya; Miyahara, Satoko; Mori, Akitane; Masuda, Yu.

In: Acta Oto-Laryngologica, Supplement, No. 523, 1996, p. 120-123.

Research output: Contribution to journalArticle

Lai, MT, Ohmichi, T, Miyahara, S, Mori, A & Masuda, Y 1996, 'Superoxide dismutases in human palatine tonsils', Acta Oto-Laryngologica, Supplement, no. 523, pp. 120-123.
Lai MT, Ohmichi T, Miyahara S, Mori A, Masuda Y. Superoxide dismutases in human palatine tonsils. Acta Oto-Laryngologica, Supplement. 1996;(523):120-123.
Lai, Ming Tang ; Ohmichi, Takuya ; Miyahara, Satoko ; Mori, Akitane ; Masuda, Yu. / Superoxide dismutases in human palatine tonsils. In: Acta Oto-Laryngologica, Supplement. 1996 ; No. 523. pp. 120-123.
@article{1536e4b842844144bd31dd6502ee97df,
title = "Superoxide dismutases in human palatine tonsils",
abstract = "In order to investigate the protective system of human palatine tonsils against the cytotoxic superoxide radicals (O2-) generated from the oxygen-related bactericidal system, immunohistochemistry and electron spin resonance (ESR) spectrometry were used to detect the distribution and activities of superoxide dismutases (SODs) in tonsils of different related systemic diseases. Immunohistochemistry showed that SODs distribute in extrafollicular lymphatic tissue and crypt epithelium. No distribution difference could be found between tonsils of different related systemic diseases. ESR revealed no significant difference between SODs activities in tonsils of different related systemic diseases. However, the mitochondrial SOD activity was found to constitute approximately 50{\%}-60{\%} of the total tonsillar cellular SODs activity. The results suggest: i) tonsils possess the ability to control cytotoxic O2-, ii) crypt epithelium and extrafollicular lymphatic tissue may encounter more O2- threat, iii) SODs may be important in protecting germinal centers from O2- injury, and iv) systemic diseases are less related to the local expression of tonsillar SODs.",
keywords = "Palatine tonsil, Superoxide dismutases, Superoxide radical",
author = "Lai, {Ming Tang} and Takuya Ohmichi and Satoko Miyahara and Akitane Mori and Yu Masuda",
year = "1996",
language = "English",
pages = "120--123",
journal = "Acta Oto-Laryngologica, Supplement",
issn = "0365-5237",
publisher = "Taylor and Francis Ltd.",
number = "523",

}

TY - JOUR

T1 - Superoxide dismutases in human palatine tonsils

AU - Lai, Ming Tang

AU - Ohmichi, Takuya

AU - Miyahara, Satoko

AU - Mori, Akitane

AU - Masuda, Yu

PY - 1996

Y1 - 1996

N2 - In order to investigate the protective system of human palatine tonsils against the cytotoxic superoxide radicals (O2-) generated from the oxygen-related bactericidal system, immunohistochemistry and electron spin resonance (ESR) spectrometry were used to detect the distribution and activities of superoxide dismutases (SODs) in tonsils of different related systemic diseases. Immunohistochemistry showed that SODs distribute in extrafollicular lymphatic tissue and crypt epithelium. No distribution difference could be found between tonsils of different related systemic diseases. ESR revealed no significant difference between SODs activities in tonsils of different related systemic diseases. However, the mitochondrial SOD activity was found to constitute approximately 50%-60% of the total tonsillar cellular SODs activity. The results suggest: i) tonsils possess the ability to control cytotoxic O2-, ii) crypt epithelium and extrafollicular lymphatic tissue may encounter more O2- threat, iii) SODs may be important in protecting germinal centers from O2- injury, and iv) systemic diseases are less related to the local expression of tonsillar SODs.

AB - In order to investigate the protective system of human palatine tonsils against the cytotoxic superoxide radicals (O2-) generated from the oxygen-related bactericidal system, immunohistochemistry and electron spin resonance (ESR) spectrometry were used to detect the distribution and activities of superoxide dismutases (SODs) in tonsils of different related systemic diseases. Immunohistochemistry showed that SODs distribute in extrafollicular lymphatic tissue and crypt epithelium. No distribution difference could be found between tonsils of different related systemic diseases. ESR revealed no significant difference between SODs activities in tonsils of different related systemic diseases. However, the mitochondrial SOD activity was found to constitute approximately 50%-60% of the total tonsillar cellular SODs activity. The results suggest: i) tonsils possess the ability to control cytotoxic O2-, ii) crypt epithelium and extrafollicular lymphatic tissue may encounter more O2- threat, iii) SODs may be important in protecting germinal centers from O2- injury, and iv) systemic diseases are less related to the local expression of tonsillar SODs.

KW - Palatine tonsil

KW - Superoxide dismutases

KW - Superoxide radical

UR - http://www.scopus.com/inward/record.url?scp=0029657812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029657812&partnerID=8YFLogxK

M3 - Article

C2 - 9082755

AN - SCOPUS:0029657812

SP - 120

EP - 123

JO - Acta Oto-Laryngologica, Supplement

JF - Acta Oto-Laryngologica, Supplement

SN - 0365-5237

IS - 523

ER -