Superoxide dismutase in various tissues from rabbits bearing the Vx-2 carcinoma in the maxillary sinus

Y. Takada, T. Noguchi, T. Okabe, M. Kajiyama

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Distribution profiles of superoxide dismutase isoenzymes in various tissues of rabbits with the Vx-2 carcinoma in the maxillary sinus were compared with those of control rabbits. Copper- and zinc-containing superoxide dismutase (Cu,Zn-SOD) activity in the liver of rabbits decreased significantly 3 weeks after transplantation. Manganese-containing superoxide dismutase (Mn-SOD) activity did not decrease significantly within 5 weeks after transplantation. In other tissues from the tumor-bearing rabbits, Cu,Zn-SOD and Mn-SOD activities were not changed within 5 weeks. No Mn-SOD activity and low Cu,Zn-SOD activity were detected in the Vx-2 carcinoma. These results suggest that the Vx-2 carcinoma has lost most of its ability to defend against oxygen toxicity and this ability decreased only in the liver of rabbits bearing the Vx-2 carcinoma in the maxillary sinus.

Original languageEnglish
Pages (from-to)4233-4235
Number of pages3
JournalCancer Research
Volume42
Issue number10
Publication statusPublished - 1982
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Takada, Y., Noguchi, T., Okabe, T., & Kajiyama, M. (1982). Superoxide dismutase in various tissues from rabbits bearing the Vx-2 carcinoma in the maxillary sinus. Cancer Research, 42(10), 4233-4235.