SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying, Shin Tang Su, Pang Hung Hsu, Che Chang Chang, I. Ying Lin, Yu Hsuan Tseng, Ming Daw Tsai, Hsiu Ming Shih, Kuo I. Lin

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11 Citations (Scopus)

Abstract

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

Original languageEnglish
Pages (from-to)631-637
Number of pages7
JournalEMBO Reports
Volume13
Issue number7
DOIs
Publication statusPublished - Jul 2012
Externally publishedYes

Keywords

  • differentiation
  • plasma cell
  • SUMO
  • transcriptional repression

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

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  • Cite this

    Ying, H. Y., Su, S. T., Hsu, P. H., Chang, C. C., Lin, I. Y., Tseng, Y. H., Tsai, M. D., Shih, H. M., & Lin, K. I. (2012). SUMOylation of Blimp-1 is critical for plasma cell differentiation. EMBO Reports, 13(7), 631-637. https://doi.org/10.1038/embor.2012.60