SUMOylation and de-SUMOylation in response to DNA damage

Hong Dou; Chao Huang; Thang Van Nguyen; Long Sheng Lu; Edward T.H. Yeh

doi:10.1016/j.febslet.2011.04.002

SUMOylation and de-SUMOylation in response to DNA damage

Hong Dou, Chao Huang, Thang Van Nguyen, Long Sheng Lu, Edward T.H. Yeh

Research output: Contribution to journal › Review article › peer-review

67 Citations (Scopus)

Abstract

To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).

Original language	English
Pages (from-to)	2891-2896
Number of pages	6
Journal	FEBS Letters
Volume	585
Issue number	18
DOIs	https://doi.org/10.1016/j.febslet.2011.04.002
Publication status	Published - Sept 16 2011
Externally published	Yes

Keywords

Repair
Replication
RPA
SENP
SUMO

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2011.04.002

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title = "SUMOylation and de-SUMOylation in response to DNA damage",

abstract = "To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).",

keywords = "Repair, Replication, RPA, SENP, SUMO, Repair, Replication, RPA, SENP, SUMO",

author = "Hong Dou and Chao Huang and {Van Nguyen}, Thang and Lu, {Long Sheng} and Yeh, {Edward T.H.}",

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doi = "10.1016/j.febslet.2011.04.002",

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T1 - SUMOylation and de-SUMOylation in response to DNA damage

AU - Dou, Hong

AU - Huang, Chao

AU - Van Nguyen, Thang

AU - Lu, Long Sheng

AU - Yeh, Edward T.H.

PY - 2011/9/16

Y1 - 2011/9/16

N2 - To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).

AB - To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).

KW - Repair

KW - Replication

KW - RPA

KW - SENP

KW - SUMO

KW - Repair

KW - Replication

KW - RPA

KW - SENP

KW - SUMO

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U2 - 10.1016/j.febslet.2011.04.002

DO - 10.1016/j.febslet.2011.04.002

M3 - Review article

C2 - 21486569

AN - SCOPUS:80052765356

SN - 0014-5793

VL - 585

SP - 2891

EP - 2896

JO - FEBS Letters

JF - FEBS Letters

IS - 18

ER -

SUMOylation and de-SUMOylation in response to DNA damage

Abstract

Keywords

ASJC Scopus subject areas

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