SUMOylation and de-SUMOylation in response to DNA damage

Hong Dou, Chao Huang, Thang Van Nguyen, Long Sheng Lu, Edward T.H. Yeh

Research output: Contribution to journalReview articlepeer-review

59 Citations (Scopus)

Abstract

To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).

Original languageEnglish
Pages (from-to)2891-2896
Number of pages6
JournalFEBS Letters
Volume585
Issue number18
DOIs
Publication statusPublished - Sep 16 2011
Externally publishedYes

Keywords

  • Repair
  • Replication
  • RPA
  • SENP
  • SUMO

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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