SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation

Thang Van Nguyen, Pornpimon Angkasekwinai, Hong Dou, Feng Ming Lin, Long Sheng Lu, Jinke Cheng, Y. Eugene Chin, Chen Dong, Edward T H Yeh

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 inthe regulation of STAT5 activation during early lymphoid development.

Original languageEnglish
Pages (from-to)210-221
Number of pages12
JournalMolecular Cell
Volume45
Issue number2
DOIs
Publication statusPublished - Jan 27 2012
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation'. Together they form a unique fingerprint.

  • Cite this

    Van Nguyen, T., Angkasekwinai, P., Dou, H., Lin, F. M., Lu, L. S., Cheng, J., Chin, Y. E., Dong, C., & Yeh, E. T. H. (2012). SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation. Molecular Cell, 45(2), 210-221. https://doi.org/10.1016/j.molcel.2011.12.026