SUMO modification modulates the transrepression activity of PLZF

Ting Ting Chao, Che Chang Chang, Hsiu Ming Shih

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Small ubiquitin-like modifier (SUMO) modification has recently been shown to associate with transcriptional regulation and nuclear body formation. Here, we show that transcription factor PLZF can be SUMO modified at lysine residue 242, 387 and 396. Converting these three SUMO acceptor Lys to Arg 3KR does not significantly affect PLZF nuclear body formation, which is distinct from the scenario of PML sumoylation in PML nuclear body formation. Furthermore, PLZF-3KR markedly reduced the transcriptional repression activity, correlating with a loss of PLZF-mediated growth suppression. These results reveal an important role of SUMO modification in PLZF-mediated transcriptional repression.

Original languageEnglish
Pages (from-to)475-482
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume358
Issue number2
DOIs
Publication statusPublished - Jun 29 2007
Externally publishedYes

Keywords

  • Nuclear body
  • PLZF
  • SUMO modification
  • Transcriptional repression

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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