Successful unrelated mismatched cord blood transplantation in an infant with severe combined immunodeficiency and Mycobacterium bovis bacillus Calmette-Guèrin disease

Tang Her Jaing; Wen I. Lee; Tzou Yien Lin; Jing Long Huang; Shih Hsiang Chen; Robert Chow

doi:10.1111/j.1399-3046.2006.00490.x

Successful unrelated mismatched cord blood transplantation in an infant with severe combined immunodeficiency and Mycobacterium bovis bacillus Calmette-Guèrin disease

Tang Her Jaing, Wen I. Lee, Tzou Yien Lin, Jing Long Huang, Shih Hsiang Chen, Robert Chow

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The case reported here of an infant who presented with Pneumocystis carinii pneumonia, CD4⁺ lymphopenia, and hypogammaglobulinemia attributable to severe combined immunodeficiency (SCID). This report discussed treatment of Mycobacterium bovis bacillus Calmette-Guèrin disease with unrelated cord blood transplantation in addition to antituberculous therapy, by adoptively transferring donor immunity with induction of mixed chimerism. Because of the unique nature of umbilical cord blood hematopoietic cells, engraftment without conditioning may be possible in SCID patients without fully matched donors.

Original language	English
Pages (from-to)	501-504
Number of pages	4
Journal	Pediatric Transplantation
Volume	10
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-3046.2006.00490.x
Publication status	Published - Jun 2006
Externally published	Yes

Keywords

Bacillus Calmette-Guèrin
Mycobacterium bovis
Severe combined immunodeficiency
Unrelated mismatched cord blood transplantation

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1111/j.1399-3046.2006.00490.x

Cite this

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abstract = "The case reported here of an infant who presented with Pneumocystis carinii pneumonia, CD4+ lymphopenia, and hypogammaglobulinemia attributable to severe combined immunodeficiency (SCID). This report discussed treatment of Mycobacterium bovis bacillus Calmette-Gu{\`e}rin disease with unrelated cord blood transplantation in addition to antituberculous therapy, by adoptively transferring donor immunity with induction of mixed chimerism. Because of the unique nature of umbilical cord blood hematopoietic cells, engraftment without conditioning may be possible in SCID patients without fully matched donors.",

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AU - Jaing, Tang Her

AU - Lee, Wen I.

AU - Lin, Tzou Yien

AU - Huang, Jing Long

AU - Chen, Shih Hsiang

AU - Chow, Robert

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Y1 - 2006/6

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AB - The case reported here of an infant who presented with Pneumocystis carinii pneumonia, CD4+ lymphopenia, and hypogammaglobulinemia attributable to severe combined immunodeficiency (SCID). This report discussed treatment of Mycobacterium bovis bacillus Calmette-Guèrin disease with unrelated cord blood transplantation in addition to antituberculous therapy, by adoptively transferring donor immunity with induction of mixed chimerism. Because of the unique nature of umbilical cord blood hematopoietic cells, engraftment without conditioning may be possible in SCID patients without fully matched donors.

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Successful unrelated mismatched cord blood transplantation in an infant with severe combined immunodeficiency and Mycobacterium bovis bacillus Calmette-Guèrin disease

Abstract

Keywords

ASJC Scopus subject areas

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