Successful unrelated mismatched cord blood transplantation in an infant with severe combined immunodeficiency and Mycobacterium bovis bacillus Calmette-Guèrin disease

Tang Her Jaing, Wen I. Lee, Tzou Yien Lin, Jing Long Huang, Shih Hsiang Chen, Robert Chow

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The case reported here of an infant who presented with Pneumocystis carinii pneumonia, CD4+ lymphopenia, and hypogammaglobulinemia attributable to severe combined immunodeficiency (SCID). This report discussed treatment of Mycobacterium bovis bacillus Calmette-Guèrin disease with unrelated cord blood transplantation in addition to antituberculous therapy, by adoptively transferring donor immunity with induction of mixed chimerism. Because of the unique nature of umbilical cord blood hematopoietic cells, engraftment without conditioning may be possible in SCID patients without fully matched donors.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalPediatric Transplantation
Volume10
Issue number4
DOIs
Publication statusPublished - Jun 2006
Externally publishedYes

Keywords

  • Bacillus Calmette-Guèrin
  • Mycobacterium bovis
  • Severe combined immunodeficiency
  • Unrelated mismatched cord blood transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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