Successful unrelated cord blood transplantation in a child with β-thalassemia major

Tang Her Jaing, Iou Jih Hung, Chao Ping Yang, Tzou Yien Lin, Robert Chow, Suh Ing Hsieh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report here the first successful transplant of unrelated umbilical cord blood (UCB) for a child with β-thalassemia major in Taiwan. A total of 2.48 × 105 /kg CD34 cells were infused into a 31/2-year-old girl following conditioning with a pre-transplant cytoreductive/immunosuppressive regimen of busulfan and cyclophosphamide. The absolute neutrophil count first exceeded 0.5 × 109/l on day 17, and the patient became red cell- and platelet-independent on days 34 and 49, respectively. Engraftment of donor hematopoietic populations was documented by cytogenetic analysis, hemoglobin electrophoresis, Southern blot analysis for thalassemia markers, and molecular analysis of short tandem repeats sequences. The patient was ex-thalassemic for more than 15 months post transplant. From this experience, it is postulated that UCB will indeed allow us to expand the available donor pool for recipients with an HLA DRB1 mismatched at one locus and reduce the risk of graft-versus-host disease.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalJournal of Tropical Pediatrics
Volume51
Issue number2
DOIs
Publication statusPublished - Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Immunology

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