Successful treatment with granulocyte-colony stimulating factor for ritodrine-induced neutropenia in a twin pregnancy

Chen Yu Wang, Yu Ju Lai, Kwei Shuai Hwang, Chi Huang Chen, Mu Hsien Yu, Huei Tsung Chen, Her Young Su

Research output: Contribution to journalArticle

Abstract

Objective Neutropenia developed after continuous intravenous infusion of ritodrine hydrochloride (Yutopar) for preterm uterine contractions in a twin pregnancy. We successfully returned the low neutrophil count to the normal range after discontinuation of infusion of ritodrine and treatment with granulocyte colony stimulating factor (G-CSF). Case Report A 34-year-old woman with twin pregnancy was treated with ritodrine for preterm uterine contractions at 27 weeks and 6 days gestation. Neutropenia developed after continuous intravenous infusion of ritodrine for about 4 weeks. We ceased the ritodrine infusion immediately and treated the neutropenia with G-CSF. A cesarean delivery was performed the day after cessation of the ritodrine infusion because of uncontrolled preterm labor. There were no adverse side effects or infectious complications in the mother or the newborns. The maternal neutrophil count recovered to the normal range 4 days after administration of G-CSF. Conclusion Based on prior case reports and the clinical presentation of our case, G-CSF may be a useful treatment for pregnant women with ritodrine-induced neutropenia. However, more clinical studies are required to confirm the safety and efficacy of this treatment.

Original languageEnglish
Pages (from-to)738-740
Number of pages3
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume55
Issue number5
DOIs
Publication statusPublished - Oct 1 2016

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Ritodrine
Twin Pregnancy
Granulocyte Colony-Stimulating Factor
Neutropenia
Uterine Contraction
Therapeutics
Intravenous Infusions
Reference Values
Neutrophils
Mothers
Premature Obstetric Labor
Pregnant Women
Newborn Infant
Safety
Pregnancy

Keywords

  • neutropenia
  • preterm labor
  • preterm uterine contractions
  • ritodrine
  • tocolysis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Successful treatment with granulocyte-colony stimulating factor for ritodrine-induced neutropenia in a twin pregnancy. / Wang, Chen Yu; Lai, Yu Ju; Hwang, Kwei Shuai; Chen, Chi Huang; Yu, Mu Hsien; Chen, Huei Tsung; Su, Her Young.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 55, No. 5, 01.10.2016, p. 738-740.

Research output: Contribution to journalArticle

Wang, Chen Yu ; Lai, Yu Ju ; Hwang, Kwei Shuai ; Chen, Chi Huang ; Yu, Mu Hsien ; Chen, Huei Tsung ; Su, Her Young. / Successful treatment with granulocyte-colony stimulating factor for ritodrine-induced neutropenia in a twin pregnancy. In: Taiwanese Journal of Obstetrics and Gynecology. 2016 ; Vol. 55, No. 5. pp. 738-740.
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