Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy

Hsin Ming Chen, Chin Tin Chen, Hsiang Yang, Mark Yen Ping Kuo, Ying Shiung Kuo, Wan Hong Lan, Yi Ping Wang, Tsuimin Tsai, Chun Pin Chiang

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67 Citations (Scopus)

Abstract

Previous studies have shown a selective accumulation of 5-aminolevulinic acid (ALA)-derived protoporphrin IX (PpIX) in oral premalignant and malignant tissues. This provides a biologic rationale for the clinical use of ALA-mediated PDT (ALA-PDT) for oral premalignant and malignant lesions. In this study, five patients with oral verrucous hyperplasia (OVH) were treated with a new protocol of ALA-PDT composed of multiple 3-min irradiations with a light emitting diode (LED) red light at 635±5 nm separated with several 3-min rests for a total of 1000 s (fluence rate, 100 mW/cm2; light exposure dose, 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h. Topical ALA-PDT was repeated once a week until the complete regression of the lesion. Complete regression of all OVH lesions was observed after 1-3 treatments (average, 2 treatments) of topical ALA-PDT. At an average follow-up of 5.6 months (range, 3-11 months), all the five OVH patients were free of tumor recurrence. We conclude that topical ALA-PDT with fractionated irradiations by an LED red light at 635±5 nm is an effective and successful treatment modality for OVH.

Original languageEnglish
Pages (from-to)630-637
Number of pages8
JournalOral Oncology
Volume40
Issue number6
DOIs
Publication statusPublished - Jul 2004

Keywords

  • 5-aminolevulinic acid
  • Oral verrucous hyperplasia
  • Photodynamic therapy

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Chen, H. M., Chen, C. T., Yang, H., Kuo, M. Y. P., Kuo, Y. S., Lan, W. H., Wang, Y. P., Tsai, T., & Chiang, C. P. (2004). Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy. Oral Oncology, 40(6), 630-637. https://doi.org/10.1016/j.oraloncology.2003.12.010