Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy

Hsin Ming Chen, Chin Tin Chen, Hsiang Yang, Mark Yen Ping Kuo, Ying Shiung Kuo, Wan Hong Lan, Yi Ping Wang, Tsuimin Tsai, Chun Pin Chiang

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Previous studies have shown a selective accumulation of 5-aminolevulinic acid (ALA)-derived protoporphrin IX (PpIX) in oral premalignant and malignant tissues. This provides a biologic rationale for the clinical use of ALA-mediated PDT (ALA-PDT) for oral premalignant and malignant lesions. In this study, five patients with oral verrucous hyperplasia (OVH) were treated with a new protocol of ALA-PDT composed of multiple 3-min irradiations with a light emitting diode (LED) red light at 635±5 nm separated with several 3-min rests for a total of 1000 s (fluence rate, 100 mW/cm2; light exposure dose, 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h. Topical ALA-PDT was repeated once a week until the complete regression of the lesion. Complete regression of all OVH lesions was observed after 1-3 treatments (average, 2 treatments) of topical ALA-PDT. At an average follow-up of 5.6 months (range, 3-11 months), all the five OVH patients were free of tumor recurrence. We conclude that topical ALA-PDT with fractionated irradiations by an LED red light at 635±5 nm is an effective and successful treatment modality for OVH.

Original languageEnglish
Pages (from-to)630-637
Number of pages8
JournalOral Oncology
Volume40
Issue number6
DOIs
Publication statusPublished - Jul 2004

Fingerprint

Aminolevulinic Acid
Photochemotherapy
Hyperplasia
Light
Therapeutics
1-phenyl-3,3-dimethyltriazene
Recurrence

Keywords

  • 5-aminolevulinic acid
  • Oral verrucous hyperplasia
  • Photodynamic therapy

ASJC Scopus subject areas

  • Oncology

Cite this

Chen, H. M., Chen, C. T., Yang, H., Kuo, M. Y. P., Kuo, Y. S., Lan, W. H., ... Chiang, C. P. (2004). Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy. Oral Oncology, 40(6), 630-637. https://doi.org/10.1016/j.oraloncology.2003.12.010

Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy. / Chen, Hsin Ming; Chen, Chin Tin; Yang, Hsiang; Kuo, Mark Yen Ping; Kuo, Ying Shiung; Lan, Wan Hong; Wang, Yi Ping; Tsai, Tsuimin; Chiang, Chun Pin.

In: Oral Oncology, Vol. 40, No. 6, 07.2004, p. 630-637.

Research output: Contribution to journalArticle

Chen, HM, Chen, CT, Yang, H, Kuo, MYP, Kuo, YS, Lan, WH, Wang, YP, Tsai, T & Chiang, CP 2004, 'Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy', Oral Oncology, vol. 40, no. 6, pp. 630-637. https://doi.org/10.1016/j.oraloncology.2003.12.010
Chen, Hsin Ming ; Chen, Chin Tin ; Yang, Hsiang ; Kuo, Mark Yen Ping ; Kuo, Ying Shiung ; Lan, Wan Hong ; Wang, Yi Ping ; Tsai, Tsuimin ; Chiang, Chun Pin. / Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy. In: Oral Oncology. 2004 ; Vol. 40, No. 6. pp. 630-637.
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