Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy

Hsin Ming Chen, Chin Tin Chen, Hsiang Yang, Ming I. Lee, Mark Yen Ping Kuo, Ying Shiung Kuo, Yi Ping Wang, Tsuimin Tsai, Chun Pin Chiang

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalJournal of Oral Pathology and Medicine
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2005

Fingerprint

Verrucous Carcinoma
Aminolevulinic Acid
Photochemotherapy
Light
Areca
Mouth Mucosa
Therapeutics
Clinical Protocols
Hyperplasia
Mouth
Neoplasms
Recurrence

Keywords

  • 5-aminolevulinic acid
  • Photodynamic therapy
  • Verrucous carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy. / Chen, Hsin Ming; Chen, Chin Tin; Yang, Hsiang; Lee, Ming I.; Kuo, Mark Yen Ping; Kuo, Ying Shiung; Wang, Yi Ping; Tsai, Tsuimin; Chiang, Chun Pin.

In: Journal of Oral Pathology and Medicine, Vol. 34, No. 4, 04.2005, p. 253-256.

Research output: Contribution to journalArticle

Chen, Hsin Ming ; Chen, Chin Tin ; Yang, Hsiang ; Lee, Ming I. ; Kuo, Mark Yen Ping ; Kuo, Ying Shiung ; Wang, Yi Ping ; Tsai, Tsuimin ; Chiang, Chun Pin. / Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy. In: Journal of Oral Pathology and Medicine. 2005 ; Vol. 34, No. 4. pp. 253-256.
@article{2f03dd4ed24244e5883ce38e2acc6a9a,
title = "Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy",
abstract = "Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20{\%} ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20{\%} ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.",
keywords = "5-aminolevulinic acid, Photodynamic therapy, Verrucous carcinoma",
author = "Chen, {Hsin Ming} and Chen, {Chin Tin} and Hsiang Yang and Lee, {Ming I.} and Kuo, {Mark Yen Ping} and Kuo, {Ying Shiung} and Wang, {Yi Ping} and Tsuimin Tsai and Chiang, {Chun Pin}",
year = "2005",
month = "4",
doi = "10.1111/j.1600-0714.2004.00267.x",
language = "English",
volume = "34",
pages = "253--256",
journal = "Journal of Oral Pathology and Medicine",
issn = "0904-2512",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy

AU - Chen, Hsin Ming

AU - Chen, Chin Tin

AU - Yang, Hsiang

AU - Lee, Ming I.

AU - Kuo, Mark Yen Ping

AU - Kuo, Ying Shiung

AU - Wang, Yi Ping

AU - Tsai, Tsuimin

AU - Chiang, Chun Pin

PY - 2005/4

Y1 - 2005/4

N2 - Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.

AB - Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.

KW - 5-aminolevulinic acid

KW - Photodynamic therapy

KW - Verrucous carcinoma

UR - http://www.scopus.com/inward/record.url?scp=15944392867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15944392867&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0714.2004.00267.x

DO - 10.1111/j.1600-0714.2004.00267.x

M3 - Article

C2 - 15752262

AN - SCOPUS:15944392867

VL - 34

SP - 253

EP - 256

JO - Journal of Oral Pathology and Medicine

JF - Journal of Oral Pathology and Medicine

SN - 0904-2512

IS - 4

ER -