Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma

Mei Jou Chen, Jehn Hsiahn Yang, Tusi Lien Mao, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: To present a case of successful pregnancy after conservative bilateral gonadectomy without adjuvant chemotherapy and radiotherapy in a 46,XY gonadal dysgenetic woman with gonadoblastoma and malignant germ cell tumor. Design: Case report. Setting: Infertility center in university hospital. Patient(s): An 18-year-old female with 46,XY karyotype underwent bilateral gonadectomy, and the pathology revealed gonadoblastoma with malignant mixed germ cell tumor. Intervention(s): Chromosomal analysis, bilateral gonadectomy, donor oocyte, and IVF program. Main Outcome Measure(s): Tumor markers and pregnancy result. Result(s): The patient was free from tumor recurrence after 13 years' follow-up. A successful twin pregnancy was achieved after oocyte donation and IVF. Conclusion(s): Gonadectomy without adjuvant therapies could be done in 46,XY gonadal dysgenetic women with gonadoblastoma in view of preservation of future fertility.

Original languageEnglish
Pages (from-to)217.e5-217.e6
JournalFertility and Sterility
Volume84
Issue number1
DOIs
Publication statusPublished - Jan 1 2005
Externally publishedYes

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46,XY Gonadal Dysgenesis
Gonadoblastoma
Germ Cell and Embryonal Neoplasms
Pregnancy
Oocyte Donation
Malignant Mixed Tumor
Fertility Preservation
Adjuvant Radiotherapy
Twin Pregnancy
Adjuvant Chemotherapy
Tumor Biomarkers
Karyotype
Infertility
Oocytes
Outcome Assessment (Health Care)
Tissue Donors
Pathology
Recurrence
Neoplasms
Therapeutics

Keywords

  • 46,XY
  • Donor oocyte
  • Gonadal dysgenesis
  • Gonadoblastoma
  • Pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma. / Chen, Mei Jou; Yang, Jehn Hsiahn; Mao, Tusi Lien; Ho, Hong Nerng; Yang, Yu Shih.

In: Fertility and Sterility, Vol. 84, No. 1, 01.01.2005, p. 217.e5-217.e6.

Research output: Contribution to journalArticle

Chen, Mei Jou ; Yang, Jehn Hsiahn ; Mao, Tusi Lien ; Ho, Hong Nerng ; Yang, Yu Shih. / Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma. In: Fertility and Sterility. 2005 ; Vol. 84, No. 1. pp. 217.e5-217.e6.
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