Successful allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in a patient with severe aplastic anemia and active infection

Tso Fu Wang, Yi Feng Wu, Yu Huai Ho, Shih Che Huang, Sung Chao Chu, Ruey Ho Kao

Research output: Contribution to journalArticlepeer-review

Abstract

Infection is the major cause of mortality in patients with severe aplastic anemia (SAA) and often results in postponement of immunotherapy or transplantation treatment. We report on a 23-year-old man with very SAA with almost no neutrophils who was primarily treated with peripheral blood stem cell transplantation from an HLA-identical sibling. He received reduced dose conditioning with cyclophosphamide and antithymocyte globulin during active infection with typhlitis and pneumonia. Cyclophosphamide 50. mg/kg/d was given on Day 4 and Day 3 before transplantation and antithymocyte globulin Fresenius 20. mg/kg/d was given on Day 3 and Day 2. Neutrophils and platelets were engrafted on Day +18 and Day +20 after transplantation. Symptoms and signs of acute or chronic graft versus host disease were not observed as of Day +545 after transplantation. Allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning may be considered as the primary therapy for SAA complicated by severe infection.

Original languageEnglish
Pages (from-to)100-102
Number of pages3
JournalTzu Chi Medical Journal
Volume23
Issue number3
DOIs
Publication statusPublished - Sep 1 2011
Externally publishedYes

Keywords

  • Hematopoietic stem cell transplantation
  • Infection
  • Reduced intensity conditioning
  • Severe aplastic anemia

ASJC Scopus subject areas

  • Medicine(all)

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