Substituent Effect on the Chlorination of 2-Alkoxypyridines to give 2-Chloropyridines under Vilsmeier-Haack Conditions

Long Li Lai, Pen Yuan Lin, Jy Shih Wang, Jih Ru Hwu, Min Jen Shiao, Shwu Chen Tsay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yields by use of POCl3 and DMF, in which the methyl, halogen, ester and nitro groups displayed an activating effect; in contrast, an amino group exhibited a deactivating effect.

Original languageEnglish
Pages (from-to)194-195
Number of pages2
JournalJournal of Chemical Research - Part S
Issue number4
Publication statusPublished - Apr 1996
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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