Subclassification, molecular structure, function and ligand in integrin superfamily

N. Matsuura, Y. Takada

Research output: Contribution to journalArticle

Abstract

Integrins are the major family of cell surface receptors that mediate adhesion to the extracellular matrix and sometimes cell-cell adhesive interactions. These integrin-mediated adhesive interactions are involved in the regulation of many cellular functions, including embryonic development, tumor cell growth and metastasis, programmed cell death, hemostasis, inflammation, immune reaction, bone reabsorption, etc. Integrins are composed of alpha and beta transmembrane subunits selected from among 16 alpha and 8 beta subunits that heterodimerize to produce more than 20 different receptors which bind specific ligands. Ligand binding sites have been clarified by chimera integrin protein in some integrins. Integrins link to intracellular cytoskeletal complexes and bundles of actin filaments. There have been many reports about intracellular signaling pathways activated by integrin-ligand interactions.

Original languageEnglish
Pages (from-to)1623-1630
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Volume53
Issue number7
Publication statusPublished - Jul 1995
Externally publishedYes

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Molecular Structure
Integrins
Ligands
Adhesives
Integrin beta Chains
Integrin alpha Chains
Cell Surface Receptors
Hemostasis
Actin Cytoskeleton
Cell Communication
Embryonic Development
Extracellular Matrix
Cell Death
Binding Sites
Neoplasm Metastasis
Inflammation
Bone and Bones
Growth
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Subclassification, molecular structure, function and ligand in integrin superfamily. / Matsuura, N.; Takada, Y.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 53, No. 7, 07.1995, p. 1623-1630.

Research output: Contribution to journalArticle

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